UniProt Q02108
Guanylate cyclase soluble subunit alpha-1 (Q02108)
Guanylate cyclase soluble subunit alpha-1 (UniProt Q02108), EC 4.6.1.2: 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q02108
- Protein
- Guanylate cyclase soluble subunit alpha-1
- EC
- 4.6.1.2
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 24 · 2 records with a druggable one
Structures
15 records of Q02108 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UVJ | Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. | x-ray diffraction | A, C | — | — |
| 3UVJ | Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. | x-ray diffraction | A, C | — | — |
| 4NI2 | Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase | x-ray diffraction | A | — | — |
| 4NI2 | Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase | x-ray diffraction | A | — | — |
| 6JT0 | Structure of human soluble guanylate cyclase in the unliganded state | electron microscopy | A | — | — |
| 6JT0 | Structure of human soluble guanylate cyclase in the unliganded state | electron microscopy | A | — | — |
| 6JT1 | Structure of human soluble guanylate cyclase in the heme oxidised state | electron microscopy | A | — | — |
| 6JT2 | Structure of human soluble guanylate cyclase in the no activated state | electron microscopy | A | G2P, MG | — |
| 7D9R | Structure of huamn soluble guanylate cyclase in the riociguat and no- bound state | electron microscopy | A | G2P, MG, GZO | — |
| 7D9S | Structure of huamn soluble guanylate cyclase in the YC1 and no-bound state | electron microscopy | A | MG, YC1, G2P | — |
| 7D9T | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | electron microscopy | A | — | — |
| 7D9U | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | electron microscopy | A | G2P, MG | — |
| 8HBE | Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom | electron microscopy | A | — | 11 (best 0.81) |
| 8HBH | Structure of human soluble guanylate cyclase in the NO-activated state at 3.1 angstrom | electron microscopy | A | MG, G2P | 13 (best 0.85) |
| Q02108 | AlphaFold monomer V2.0 prediction for guanylate cyclase soluble subunit alpha-1 (Q02108) | predicted | A | — | — |
Ligands
- G2P · Phosphomethylphosphonic acid guanylate ester · in 5 records
- MG · Magnesium ion · in 5 records
- GZO · Methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl) methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate · in 1 record
- YC1 · [5-[1-(phenylmethyl)indazol-3-yl]furan-2-yl]methanol · in 1 record
Experiment against prediction
- 3UVJ chain A against the predicted model Q02108: TM-score 0.96, RMSD 1.49 Å
- 3UVJ chain A against the predicted model Q02108: TM-score 0.96, RMSD 1.49 Å
- 3UVJ chain C against the predicted model Q02108: TM-score 0.95, RMSD 1.75 Å
- 3UVJ chain C against the predicted model Q02108: TM-score 0.95, RMSD 1.75 Å
- 4NI2 chain A against the predicted model Q02108: TM-score 0.95, RMSD 1.42 Å
- 4NI2 chain A against the predicted model Q02108: TM-score 0.95, RMSD 1.42 Å
- 7D9R chain A against the predicted model Q02108: TM-score 0.66, RMSD 4.67 Å
- 7D9S chain A against the predicted model Q02108: TM-score 0.66, RMSD 4.65 Å
- 6JT2 chain A against the predicted model Q02108: TM-score 0.66, RMSD 4.51 Å
- 8HBH chain A against the predicted model Q02108: TM-score 0.65, RMSD 4.52 Å
Elsewhere
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