UniProt Q00194

cGMP-gated cation channel alpha-1 (Q00194)

cGMP-gated cation channel alpha-1 (UniProt Q00194): 4 experimental structures and 1 predicted model on GenesisL1, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q00194
Protein: cGMP-gated cation channel alpha-1
Experimental structures: 4
Predicted models: 1
Pockets: 19 · 1 record with a druggable one

Structures

5 records of Q00194 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3SWF	CNGA1 621-690 containing CLZ domain	x-ray diffraction	A, B, C	—	—
3SWF	CNGA1 621-690 containing clz domain	x-ray diffraction	A, B, C	—	—
7O4H	The structure of the native CNGA1/CNGB1 CNG channel from retinal rods	electron microscopy	A, B, C	—	19 (best 0.86)
7O4H	The structure of the native CNGA1/CNGB1 cng channel from retinal rods	electron microscopy	A, B, C	—	—
Q00194	AlphaFold monomer V2.0 prediction for cgmp-gated cation channel alpha-1 (Q00194)	predicted	A	—	—

Experiment against prediction

7O4H chain C against the predicted model Q00194: TM-score 0.84, RMSD 3.64 Å
7O4H chain C against the predicted model Q00194: TM-score 0.84, RMSD 3.64 Å
7O4H chain A against the predicted model Q00194: TM-score 0.83, RMSD 3.74 Å
7O4H chain A against the predicted model Q00194: TM-score 0.83, RMSD 3.74 Å
7O4H chain B against the predicted model Q00194: TM-score 0.81, RMSD 3.95 Å
7O4H chain B against the predicted model Q00194: TM-score 0.81, RMSD 3.95 Å
3SWF chain C against the predicted model Q00194: TM-score 0.81, RMSD 1.78 Å
3SWF chain C against the predicted model Q00194: TM-score 0.81, RMSD 1.78 Å
3SWF chain A against the predicted model Q00194: TM-score 0.80, RMSD 1.66 Å
3SWF chain A against the predicted model Q00194: TM-score 0.80, RMSD 1.66 Å

Elsewhere

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