MolNFT v1 · #79206 · protein

CNGA1 621-690 containing clz domain

3SWF · Cgmp-gated cation channel alpha-1: “CNGA1 621-690 containing clz domain”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.50). MolNFT v1 #79206 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3SWF
Type: protein
Length: 165 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cgmp-gated cation channel alpha-1
UniProt: Q00194
Ligands: ZN
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 3 distinct chains · 92% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cgmp-gated cation channel alpha-1	protein	56	93% helix, 0% strand	Q00194
B	Cgmp-gated cation channel alpha-1	protein	58	95% helix, 0% strand	Q00194
C	Cgmp-gated cation channel alpha-1	protein	51	86% helix, 0% strand	Q00194

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.50	0.85	13	empty

Interfaces

3 interfaces between chains.

A–B · 1158 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 1036 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 1012 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

3SWF · CNGA1 621-690 containing CLZ domain · the same entry in another collection · chain A against A, TM-score 1.00
Q00194 · AlphaFold monomer V2.0 prediction for cgmp-gated cation channel alpha-1 (Q00194) · a predicted model of the same protein · chain C against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00194
Elsewhere: RCSB PDB 3SWF · PDBe 3SWF · UniProt Q00194

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