MolNFT v1 · #183830 · protein
The structure of the native CNGA1/CNGB1 cng channel from retinal rods
7O4H · Cgmp-gated cation channel alpha-1: “The structure of the native CNGA1/CNGB1 cng channel from retinal rods”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #183830 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7O4H
- Type
- protein
- Length
- 1,780 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cgmp-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel beta-1
- UniProt
- Q00194, Q28181
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 4 distinct chains · 51% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cgmp-gated cation channel alpha-1 | protein | 465 | 50% helix, 4% strand | Q00194 |
| B | Cgmp-gated cation channel alpha-1 | protein | 468 | 48% helix, 4% strand | Q00194 |
| C | Cgmp-gated cation channel alpha-1 | protein | 464 | 53% helix, 4% strand | Q00194 |
| D | Cyclic nucleotide-gated cation channel beta-1 | protein | 383 | 55% helix, 5% strand | Q28181 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 714 | 0.86 | 0.89 | 104 | empty |
| 2 | 733 | 0.85 | 0.88 | 98 | empty |
| 3 | 389 | 0.77 | 0.86 | 46 | empty |
| 4 | 925 | 0.77 | 0.79 | 93 | empty |
| 5 | 574 | 0.76 | 0.83 | 47 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1918 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 1867 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 1664 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 1606 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 36 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7O4H · The structure of the native CNGA1/CNGB1 CNG channel from retinal rods · the same entry in another collection · chain D against D, TM-score 1.00
- Q00194 · AlphaFold monomer V2.0 prediction for cgmp-gated cation channel alpha-1 (Q00194) · a predicted model of the same protein · chain C against A, TM-score 0.84
- Q28181 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated cation channel beta-1… · a predicted model of the same protein · chain D against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00194
- Every structure of UniProt Q28181
- Elsewhere: RCSB PDB 7O4H · PDBe 7O4H · UniProt Q00194 · UniProt Q28181
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.