UniProt P9WK11
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (P9WK11)
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (UniProt P9WK11), EC 2.2.1.9: 20 experimental structures on GenesisL1, 10 ligands bound, 120 pockets. Binding sites, pockets, druggability and 3D structures…
- UniProt
- P9WK11
- Protein
- 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- EC
- 2.2.1.9
- Experimental structures
- 20
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 120 · 6 records with a druggable one
Structures
20 records of P9WK11 in the MolNFT archive: 20 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ERX | Crystal Structure of APO MenD from M. tuberculosis - I222 | x-ray diffraction | A | — | — |
| 5ERX | Crystal structure of apo mend from M. tuberculosis - I222 | x-ray diffraction | A | — | — |
| 5ERY | Crystal structure of apo mend from M. tuberculosis - P212121 | x-ray diffraction | A, D, C, B | — | — |
| 5ESD | Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+ | x-ray diffraction | A, B, C, D | MN, TPP | 20 (best 0.86) |
| 5ESD | Crystal structure of M. tuberculosis mend bound to thdp and MN2+ | x-ray diffraction | A, B, C, D | — | — |
| 5ESO | Crystal Structure of M. tuberculosis MenD with ThDP, Mg2+ and Isochorismate bound | x-ray diffraction | A, B, C, D | MG, ISC, TPP | — |
| 5ESO | Crystal structure of M. tuberculosis mend with thdp, MG2+ and isochorismate bound | x-ray diffraction | A, B, C, D | — | — |
| 5ESS | Crystal Structure of M. tuberculosis MenD bound to Mg2+ and covalent intermediate I (a ThDP and… | x-ray diffraction | A, B, C, D | MG, DPO, TOG | 20 (best 0.86) |
| 5ESS | Crystal structure of M. tuberculosis mend bound to MG2+ and covalent intermediate I (a thdp and… | x-ray diffraction | A, B, C, D | — | — |
| 5ESU | Crystal Structure of M. tuberculosis MenD bound to Mg2+ and Covalent Intermediate II (a ThDP +… | x-ray diffraction | A, B, C, D | MG, TOI | — |
| 5ESU | Crystal structure of M. tuberculosis mend bound to MG2+ and covalent intermediate II (a thdp +… | x-ray diffraction | A, B, C, D | — | — |
| 6O04 | M.tb MenD IntII bound with Inhibitor | x-ray diffraction | A, D, B, C | DNA, MG, TOI, CL | 20 (best 0.85) |
| 6O04 | M.TB mend intii bound with inhibitor | x-ray diffraction | A, D, B, C | DNA, MG, TOI, CL | — |
| 6O0G | M.tb MenD bound to Intermediate I and Inhibitor | x-ray diffraction | A, D, B, C | DNA, AKG, TOG, MG, CL | 20 (best 0.83) |
| 6O0G | M.TB mend bound to intermediate I and inhibitor | x-ray diffraction | A, D, B, C | DNA, AKG, TOG, MG, CL | — |
| 6O0J | M.tb MenD with ThDP and Inhibitor bound | x-ray diffraction | A, D, B, C | DNA, MG, TPP | 20 (best 0.83) |
| 6O0J | M.TB mend with thdp and inhibitor bound | x-ray diffraction | A, D, B, C | DNA, MG, TPP | — |
| 6O0N | M.tb MenD with Inhibitor | x-ray diffraction | A, B, C, D | DNA | 20 (best 0.78) |
| 6O0N | M.TB mend with inhibitor | x-ray diffraction | A, B, C, D | DNA | — |
| P9WK11 | AlphaFold monomer V2.0 prediction for 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate… | — | — | — |
Ligands
- MG · Magnesium ion · in 9 records
- DNA · 1,4-dihydroxy-2-naphthoic acid · in 8 records
- CL · Chloride ion · in 4 records
- TPP · Thiamine diphosphate · in 4 records
- TOG · 4-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy) phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-4-oxidanyl-butanoic acid · in 3 records
- TOI · (1~{R},2~{S},5~{S},6~{S})-2-[(1~{S})-1-[3-[(4-azanylidene-2-methyl-1~{H}-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl (phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-1,4-bis(oxidanyl)-4-oxidanylidene-butyl]-6-oxidanyl-5-(3-oxid anyl-3-oxidanylidene-prop-1-en-2-yl)oxy-cyclohex-3-ene-1-carboxylic acid · in 3 records
- AKG · 2-oxoglutaric acid · in 2 records
- DPO · Diphosphate · in 1 record
- ISC · (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid · in 1 record
- MN · Manganese (II) ion · in 1 record
Elsewhere
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