MolNFT v1 · #118103 · protein

Crystal structure of apo mend from M. tuberculosis - I222

5ERX · 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1…: “Crystal structure of apo mend from M. tuberculosis - I222”. X-ray diffraction, 5 pockets (best druggability 0.63). MolNFT v1 #118103 on GenesisL1: 3D structure, binding sites and…

PDB: 5ERX
Type: protein
Length: 508 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase
EC: 2.2.1.9
UniProt: P9WK11
Pockets: 5 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase (EC 2.2.1.9)	protein	508	40% helix, 18% strand	P9WK11

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	403	0.63	0.78	49	empty
2	113	0.60	0.86	30	empty
3	229	0.60	0.80	37	empty
4	98	0.32	0.72	22	empty
5	56	0.31	0.76	14	empty

Compared structures

5ERX · Crystal Structure of APO MenD from M. tuberculosis - I222 · the same entry in another collection · chain A against A, TM-score 1.00
P9WK11 · AlphaFold monomer V2.0 prediction for 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-c… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WK11
Elsewhere: RCSB PDB 5ERX · PDBe 5ERX · UniProt P9WK11

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.