UniProt P97675
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (P97675)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (UniProt P97675), EC 3.1.4.1, 3.6.1.9: 12 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 115 pockets. Binding sites, druggability and…
- UniProt
- P97675
- Protein
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- EC
- 3.1.4.1, 3.6.1.9
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 115 · 6 records with a druggable one
Structures
13 records of P97675 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6F2T | Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) | x-ray diffraction | A, B | NAG, BMA, PO4, ZN, CA | 18 (best 0.63) |
| 6F2T | Crystal structure of ectonucleotide PHOSPHODIESTERASE/PYROPHOSPHATASE- 3 (NPP3) | x-ray diffraction | A, B | NAG, BMA, PO4, ZN, CA | — |
| 6F2V | Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) in complex with AMP | x-ray diffraction | A, B | NAG, BMA, AMP, ZN, CA | 17 (best 0.66) |
| 6F2V | Crystal structure of ectonucleotide PHOSPHODIESTERASE/PYROPHOSPHATASE- 3 (NPP3) in complex with AMP | x-ray diffraction | A, B | NAG, BMA, AMP, ZN, CA | — |
| 6F2Y | Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) in complex with Ap4A | x-ray diffraction | A, B | NAG, BMA, B4P, ZN, CA | 20 (best 0.68) |
| 6F2Y | Crystal structure of ectonucleotide PHOSPHODIESTERASE/PYROPHOSPHATASE- 3 (NPP3) in complex with AP4A | x-ray diffraction | A, B | NAG, BMA, B4P, ZN, CA | — |
| 6F30 | Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) in complex with… | x-ray diffraction | A, B | NAG, UD1, ZN, CA | 20 (best 0.69) |
| 6F30 | Crystal structure of ectonucleotide PHOSPHODIESTERASE/PYROPHOSPHATASE- 3 (NPP3) in complex with… | x-ray diffraction | A, B | NAG, UD1, ZN, CA | — |
| 6F33 | Crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) in complex with… | x-ray diffraction | A, B | NAG, ZAN, ZN, CA | 20 (best 0.60) |
| 6F33 | Crystal structure of ectonucleotide PHOSPHODIESTERASE/PYROPHOSPHATASE- 3 (NPP3) in complex with… | x-ray diffraction | A, B | NAG, ZAN, ZN, CA | — |
| 6G4G | Full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) including the… | x-ray diffraction | A, B, C, D | NAG, CA | 20 (best 0.76) |
| 6G4G | Full length ectodomain of ectonucleotide PHOSPHODIESTERASE/PYROPHOSPHATASE-3 (NPP3) including the… | x-ray diffraction | A, B, C, D | NAG, CA | — |
| P97675 | AlphaFold monomer V2.0 prediction for ectonucleotide PYROPHOSPHATASE/PHOSPHODIESTERASE family… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 12 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- ZN · Zinc ion · in 10 records
- BMA · beta-D-mannopyranose · in 6 records
- AMP · Adenosine monophosphate · in 2 records
- B4P · Bis(adenosine)-5'-tetraphosphate · in 2 records
- PO4 · Phosphate ion · in 2 records
- UD1 · Uridine-diphosphate-N-acetylglucosamine · in 2 records
- ZAN · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]adenosine · in 2 records
Experiment against prediction
- 6F2T chain A against the predicted model P97675: TM-score 1.00, RMSD 0.52 Å
- 6F2T chain A against the predicted model P97675: TM-score 1.00, RMSD 0.52 Å
- 6F2V chain B against the predicted model P97675: TM-score 1.00, RMSD 0.61 Å
- 6F2V chain B against the predicted model P97675: TM-score 1.00, RMSD 0.61 Å
- 6F2T chain B against the predicted model P97675: TM-score 1.00, RMSD 0.60 Å
- 6F2T chain B against the predicted model P97675: TM-score 1.00, RMSD 0.60 Å
- 6F2Y chain B against the predicted model P97675: TM-score 1.00, RMSD 0.61 Å
- 6F2Y chain B against the predicted model P97675: TM-score 1.00, RMSD 0.61 Å
- 6F2Y chain A against the predicted model P97675: TM-score 1.00, RMSD 0.62 Å
- 6F2Y chain A against the predicted model P97675: TM-score 1.00, RMSD 0.62 Å
Elsewhere
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