UniProt P80184
Tetrahydromethanopterin S-methyltransferase subunit A 1 (P80184)
Tetrahydromethanopterin S-methyltransferase subunit A 1 (UniProt P80184): 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P80184
- Protein
- Tetrahydromethanopterin S-methyltransferase subunit A 1
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 18 · 3 records with a druggable one
Structures
3 records of P80184 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8Q3V | Cryo-EM structure of the methanogenic Na+ translocating N5-methyl-H4MPT:CoM methyltransferase… | electron microscopy | A, a, Q | MG, JCV | 8 (best 0.86) |
| 8Q54 | N5-methyl-H4MPT:CoM methyltransferase -coenzyme M complex + CoM | electron microscopy | A, a, Q | MG, JCV | 9 (best 0.86) |
| P80184 | AlphaFold monomer V2.0 prediction for tetrahydromethanopterin S-methyltransferase subunit a 1… | predicted | A | — | 1 (best 0.65) |
Ligands
- JCV · [(2~{S},7~{R},11~{R},15~{S},19~{S},22~{S},26~{S},30~{R},34~{R},39~{S},43~{R},47~{R},51~{S},55~{S},58~{S},62~{S},66~{R},70~{R})-39-[[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methyl [(2~{R},3~{S},5~{R},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl] hydrogen phosphate · in 2 records
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 8Q54 chain a against the predicted model P80184: TM-score 0.58, RMSD 2.51 Å
- 8Q54 chain Q against the predicted model P80184: TM-score 0.58, RMSD 2.75 Å
- 8Q54 chain A against the predicted model P80184: TM-score 0.58, RMSD 2.77 Å
- 8Q3V chain a against the predicted model P80184: TM-score 0.57, RMSD 2.60 Å
- 8Q3V chain Q against the predicted model P80184: TM-score 0.57, RMSD 2.61 Å
- 8Q3V chain A against the predicted model P80184: TM-score 0.57, RMSD 2.57 Å
Elsewhere
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