GL1X · GenesisL1 explorer

Ligand · JCV

JCV · [(2~{S},7~{R},11~{R},15~{S},19~{S},22~{S},26~{S},30~{R},34~{R},39~{S},43~{R},47~{R},51~{S},55~{S},58~{S},62~{S},66~{R},70~{R})-39-[[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methyl [(2~{R},3~{S},5~{R},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl] hydrogen phosphate

JCV, [(2~{S},7~{R},11~{R},15~{S},19~{S},22~{S},26~{S},30~{R},34~{R},39~{S},43~{R},47~{R},51~{S},55~{S},58~{S},62~{S},66~{R},70~{R})-39-[[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-7,11,15,19,2…

Component
JCV
Formula
C98 H193 O19 P
Class
ligand
Structures
2
PDB entries
2

Binding sites

JCV in 2 structures; the first of them:

  • 8Q3V · Cryo-EM structure of the methanogenic Na+ translocating N5-methyl-H4MPT:CoM… · JCV C301 · binds ILE210, ALA213, ILE214, LEU217, PRO224, TRP226, TRP227, SER230 and 27 more
  • 8Q54 · N5-methyl-H4MPT:CoM methyltransferase -coenzyme M complex + CoM · JCV C301 · binds ILE210, ILE214, LEU217, TRP226, TRP227, SER230, LEU231, ALA234 and 24 more

Residues it binds most

LEU 24, ILE 24, PHE 24, ALA 24, VAL 22, MET 16, ARG 23, THR 23, TRP 18, GLN 12 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • NA · Sodium ion
  • COM · 1-thioethanesulfonic acid

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