UniProt P77933
DNA polymerase (P77933)
DNA polymerase (UniProt P77933), EC 2.7.7.7: 15 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P77933
- Protein
- DNA polymerase
- EC
- 2.7.7.7
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 8 · 1 record with a druggable one
Structures
16 records of P77933 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WNS | Crystal structure of family B DNA polymerase from hyperthermophilic archaeon pyrococcus… | x-ray diffraction | A | — | — |
| 1WNS | Crystal structure of family B DNA polymerase from hyperthermophilic archaeon pyrococcus… | x-ray diffraction | A | — | — |
| 2CW7 | Crystal structure of intein homing endonuclease II | x-ray diffraction | A | — | — |
| 2CW7 | Crystal structure of intein homing endonuclease II | x-ray diffraction | A | — | — |
| 2CW8 | Crystal structure of intein homing endonuclease II | x-ray diffraction | A | — | — |
| 2CW8 | Crystal structure of intein homing endonuclease II | x-ray diffraction | A | — | — |
| 4K8Z | KOD Polymerase in binary complex with dsDNA | x-ray diffraction | A | — | — |
| 4K8Z | Kod polymerase in binary complex with dsdna | x-ray diffraction | A | — | — |
| 5OMF | Closed, ternary structure of KOD DNA polymerase | x-ray diffraction | A | MN, MG, DTP | — |
| 5OMF | Closed, ternary structure of kod DNA polymerase | x-ray diffraction | A | MN, MG, DTP | — |
| 6Q4T | Kod DNA pol in a closed ternary complex with 7-deaza-7-(2-(2… | x-ray diffraction | A | MN, MG, HHZ, NO3, SO4 | — |
| 7OM3 | Crystal structure of kod DNA polymerase in a binary complex with hypoxanthine containing template | x-ray diffraction | A | BR | — |
| 7OMB | Crystal structure of kod DNA polymerase in a ternary complex with a P/T duplex containing an… | x-ray diffraction | A | DTP, MG, MN | — |
| 7OMG | Crystal structure of KOD DNA Polymerase in a ternary complex with an Uracil containing template | x-ray diffraction | A | DTP, MG, MN, CA, CL | 8 (best 0.78) |
| 7OMG | Crystal structure of kod DNA polymerase in a ternary complex with an uracil containing template | x-ray diffraction | A | DTP, MG, MN, CA, CL | — |
| P77933 | AlphaFold monomer V2.0 prediction for DNA polymerase (P77933) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 6 records
- MN · Manganese (II) ion · in 6 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 5 records
- CA · Calcium ion · in 2 records
- CL · Chloride ion · in 2 records
- BR · Bromide ion · in 1 record
- HHZ · [[(2~{R},3~{S},5~{R})-5-[4-azanyl-5-[3-[2-(2-hydroxyethyloxy)ethanoylamino]prop-1-ynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
- NO3 · Nitrate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 2CW7 chain A against the predicted model P77933: TM-score 0.95, RMSD 1.93 Å
- 2CW7 chain A against the predicted model P77933: TM-score 0.95, RMSD 1.93 Å
- 2CW8 chain A against the predicted model P77933: TM-score 0.95, RMSD 1.96 Å
- 2CW8 chain A against the predicted model P77933: TM-score 0.95, RMSD 1.96 Å
- 4K8Z chain A against the predicted model P77933: TM-score 0.92, RMSD 3.01 Å
- 4K8Z chain A against the predicted model P77933: TM-score 0.92, RMSD 3.01 Å
- 7OMB chain A against the predicted model P77933: TM-score 0.91, RMSD 3.08 Å
- 5OMF chain A against the predicted model P77933: TM-score 0.91, RMSD 3.09 Å
- 5OMF chain A against the predicted model P77933: TM-score 0.91, RMSD 3.09 Å
- 6Q4T chain A against the predicted model P77933: TM-score 0.91, RMSD 3.12 Å
Elsewhere
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