MolNFT v1 · #33821 · protein
Crystal structure of intein homing endonuclease II
2CW8 · Endonuclease pi-pkoii: “Crystal structure of intein homing endonuclease II”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.39). MolNFT v1 #33821 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2CW8
- Type
- protein
- Length
- 537 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endonuclease pi-pkoii
- EC
- 3.1.-.-
- UniProt
- P77933
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endonuclease pi-pkoii (EC 3.1.-.-) | protein | 537 | 34% helix, 32% strand | P77933 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.39 | 0.74 | 22 | SO4 |
| 2 | 92 | 0.39 | 0.77 | 14 | empty |
| 3 | 97 | 0.37 | 0.75 | 23 | empty |
| 4 | 77 | 0.35 | 0.76 | 17 | empty |
| 5 | 51 | 0.30 | 0.76 | 14 | empty |
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P77933
- Elsewhere: RCSB PDB 2CW8 · PDBe 2CW8 · UniProt P77933
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