UniProt P75958
Lipoprotein-releasing system transmembrane protein LolE (P75958)
Lipoprotein-releasing system transmembrane protein LolE (UniProt P75958): 16 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 78 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P75958
- Protein
- Lipoprotein-releasing system transmembrane protein LolE
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 78 · 7 records with a druggable one
Structures
17 records of P75958 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7ARH | LolCDE in complex with lipoprotein | electron microscopy | E | Z41, PLM | 12 (best 0.84) |
| 7ARH | Lolcde in complex with lipoprotein | electron microscopy | E | Z41, PLM | — |
| 7ARI | LolCDE apo structure | electron microscopy | E | — | 10 (best 0.76) |
| 7ARI | Lolcde apo structure | electron microscopy | E | — | — |
| 7ARJ | LolCDE in complex with lipoprotein and AMPPNP complex undimerized form | electron microscopy | E | ANP, Z41, PLM | 9 (best 0.83) |
| 7ARJ | Lolcde in complex with lipoprotein and amppnp complex undimerized form | electron microscopy | E | Z41, PLM | — |
| 7ARK | LolCDE in complex with AMP-PNP in the closed NBD state | electron microscopy | E | ANP | 13 (best 0.87) |
| 7ARK | Lolcde in complex with AMP-pnp in the closed nbd state | electron microscopy | E | ANP | — |
| 7ARL | Lolcde in complex with lipoprotein and ADP | electron microscopy | E | Z41, ADP, PLM | — |
| 7ARM | Lolcde in complex with lipoprotein and lola | electron microscopy | E | Z41, PLM | — |
| 7MDX | LolCDE nucleotide-free | electron microscopy | B | F15, ZM5 | 7 (best 0.82) |
| 7V8I | LolCD(E171Q)E with bound AMPPNP in nanodiscs | electron microscopy | E | — | 17 (best 0.85) |
| 7V8I | LOLCD(E171Q)E with bound amppnp in nanodiscs | electron microscopy | E | — | — |
| 7V8L | LolCDE with bound RcsF in nanodiscs | electron microscopy | E | PCJ | 10 (best 0.83) |
| 7V8M | LolCDE-apo in nanodiscs | electron microscopy | E | — | — |
| 7V8M | Lolcde-apo in nanodiscs | electron microscopy | E | — | — |
| P75958 | AlphaFold monomer V2.0 prediction for lipoprotein-releasing system transmembrane protein lole… | predicted | A | — | — |
Ligands
- PLM · Palmitic acid · in 6 records
- Z41 · (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate · in 6 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- F15 · Pentadecanoic acid · in 1 record
- PCJ · (2R)-3-{[(2S)-3-hydroxy-2-(palmitoylamino)propyl]thio}propane-1,2-diyl dihexadecanoate · in 1 record
- ZM5 · (2R)-2-(tridecanoyloxy)propyl hexadecanoate · in 1 record
Experiment against prediction
- 7V8M chain E against the predicted model P75958: TM-score 0.95, RMSD 1.90 Å
- 7V8M chain E against the predicted model P75958: TM-score 0.95, RMSD 1.90 Å
- 7V8L chain E against the predicted model P75958: TM-score 0.94, RMSD 1.98 Å
- 7MDX chain B against the predicted model P75958: TM-score 0.93, RMSD 2.01 Å
- 7ARH chain E against the predicted model P75958: TM-score 0.93, RMSD 2.05 Å
- 7ARH chain E against the predicted model P75958: TM-score 0.93, RMSD 2.05 Å
- 7ARJ chain E against the predicted model P75958: TM-score 0.93, RMSD 2.09 Å
- 7ARJ chain E against the predicted model P75958: TM-score 0.93, RMSD 2.09 Å
- 7ARL chain E against the predicted model P75958: TM-score 0.93, RMSD 2.12 Å
- 7ARM chain E against the predicted model P75958: TM-score 0.93, RMSD 2.10 Å
Elsewhere
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