MolNFT v1 · #189279 · protein
Lolcde-apo in nanodiscs
7V8M · Lipoprotein-releasing system transmembrane protein lolc: “Lolcde-apo in nanodiscs”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #189279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7V8M
- Type
- protein
- Length
- 1,263 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipoprotein-releasing system transmembrane protein lolc; Lipoprotein-releasing system…
- EC
- 7.6.2.-
- UniProt
- P0ADC3, P75957, P75958
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 48% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Lipoprotein-releasing system transmembrane protein lolc | protein | 396 | 51% helix, 21% strand | P0ADC3 |
| D, F | Lipoprotein-releasing system ATP-binding protein lold (EC 7.6.2.-) | protein | 229 | 35% helix, 23% strand | P75957 |
| E | Lipoprotein-releasing system transmembrane protein lole | protein | 409 | 53% helix, 17% strand | P75958 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1057 | 0.79 | 0.80 | 67 | empty |
| 2 | 67 | 0.72 | 0.97 | 16 | empty |
| 3 | 185 | 0.71 | 0.88 | 37 | empty |
| 4 | 310 | 0.71 | 0.84 | 48 | empty |
| 5 | 179 | 0.70 | 0.88 | 34 | empty |
Interfaces
4 interfaces between chains.
- C–E · 1881 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 1128 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 903 Ų buried · 4 hydrogen bonds · protein-protein
- D–F · 58 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7V8M · LolCDE-apo in nanodiscs · the same entry in another collection · chain C against C, TM-score 1.00
- P75958 · AlphaFold monomer V2.0 prediction for lipoprotein-releasing system transmembrane protein… · a predicted model of the same protein · chain E against A, TM-score 0.95
- P0ADC3 · AlphaFold monomer V2.0 prediction for lipoprotein-releasing system transmembrane protein… · a predicted model of the same protein · chain C against A, TM-score 0.92
- P75957 · AlphaFold monomer V2.0 prediction for lipoprotein-releasing system ATP-binding protein… · a predicted model of the same protein · chain D against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ADC3
- Every structure of UniProt P75957
- Every structure of UniProt P75958
- Elsewhere: RCSB PDB 7V8M · PDBe 7V8M · UniProt P0ADC3 · UniProt P75957 · UniProt P75958
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