UniProt P68105
Elongation factor 1-alpha 1 (P68105)
Elongation factor 1-alpha 1 (UniProt P68105), EC 3.6.5.-: 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P68105
- Protein
- Elongation factor 1-alpha 1
- EC
- 3.6.5.-
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 1 · 1 record with a druggable one
Structures
5 records of P68105 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LZS | Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B | electron microscopy | jj | MG, GDP, 7C4 | — |
| 8G5Z | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) | electron microscopy | EF | MG, PHE, GSP, ZIY | 1 (best 0.89) |
| 8Z70 | State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding | electron microscopy | x | — | — |
| 8Z71 | State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding | electron microscopy | x | — | — |
| P68105 | AlphaFold monomer V2.0 prediction for elongation factor 1-alpha 1 (P68105) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 2 records
- 7C4 · (2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-butan-2-yl]-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-12-oxidanyl-2,5,7,10,15,19,22-heptakis(oxidanylidene)-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-~{N}-methyl-1-[(2~{S})-2-oxidanylpropanoyl]pyrrolidine-2-carboxamide · in 1 record
- GDP · Guanosine-5'-diphosphate · in 1 record
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 1 record
- PHE · Phenylalanine · in 1 record
- ZIY · plitidepsin · in 1 record
Experiment against prediction
- 8G5Z chain EF against the predicted model P68105: TM-score 0.96, RMSD 1.51 Å
- 8Z70 chain x against the predicted model P68105: TM-score 0.96, RMSD 1.55 Å
- 8Z71 chain x against the predicted model P68105: TM-score 0.96, RMSD 1.55 Å
- 5LZS chain jj against the predicted model P68105: TM-score 0.96, RMSD 1.59 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.