UniProt P63073
Eukaryotic translation initiation factor 4E (P63073)
Eukaryotic translation initiation factor 4E (UniProt P63073): 32 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P63073
- Protein
- Eukaryotic translation initiation factor 4E
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 5 · 1 record with a druggable one
Structures
33 records of P63073 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EJ1 | Cocrystal structure of the messenger RNA 5' cap-binding protein (EIF4E) bound to 7-methyl-GDP | x-ray diffraction | A, B | — | — |
| 1EJ1 | Cocrystal structure of the messenger RNA 5' cap-binding protein (EIF4E) bound to 7-methyl-GDP | x-ray diffraction | A, B | — | — |
| 1EJ4 | Cocrystal structure of EIF4E/4E-BP1 peptide | x-ray diffraction | A | — | — |
| 1EJ4 | Cocrystal structure of EIF4E/4E-BP1 peptide | x-ray diffraction | A | — | — |
| 1EJH | EIF4E/EIF4G PEPTIDE/7-methyl-GDP | x-ray diffraction | A, B, C, D | — | — |
| 1EJH | EIF4E/EIF4G PEPTIDE/7-methyl-GDP | x-ray diffraction | A, B, C, D | — | — |
| 1L8B | Cocrystal Structure of the Messenger RNA 5' Cap-binding Protein (eIF4E) bound to 7-methylGpppG | x-ray diffraction | A, B | — | — |
| 1L8B | Cocrystal structure of the messenger RNA 5' cap-binding protein (EIF4E) bound to 7-methylgpppg | x-ray diffraction | A, B | — | — |
| 5BXV | EIF4E complex | x-ray diffraction | A, C | — | — |
| 5J5O | Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | 6G0 | — |
| 5J5O | Translation initiation factor 4E in complex with M7GPPPPG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | — | — |
| 5J5Y | Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | 6G6 | — |
| 5J5Y | Translation initiation factor 4E in complex with M2(7,2'O)GPPCCL2PPG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | — | — |
| 5M7V | Translation initiation factor 4E in complex with (rp)-M2(7,2'O)GPPSPG mRNA 5' cap analog… | x-ray diffraction | A, B, C, D | WZO | — |
| 5M7W | Translation initiation factor 4E in complex with (sp)-M2(7,2'O)GPPSPG mRNA 5' cap analog… | x-ray diffraction | A, B, C, D | WZO | — |
| 5M7X | Translation initiation factor 4E in complex with (rp)-M2(7,2'O)GPPSEPG mRNA 5' cap analog… | x-ray diffraction | A, B, C, D | RSE | — |
| 5M7Z | Translation initiation factor 4E in complex with (sp)-M2(7,2'O)GPPSEPG mRNA 5' cap analog… | x-ray diffraction | A, B, C, D | 7LO, CL | — |
| 5M80 | Translation initiation factor 4E in complex with (rp)-ipr-M7GPPSPG mRNA 5' cap analog | x-ray diffraction | A, C, B, D | 7L2 | — |
| 5M81 | Translation initiation factor 4E in complex with (SP)-iPr-m7GppSpG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | 7L2 | — |
| 5M81 | Translation initiation factor 4E in complex with (sp)-ipr-M7GPPSPG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | 7L2 | — |
| 5M83 | Translation initiation factor 4E in complex with (rp)-M2(7,2'O)GPPSPA mRNA 5' cap analog | x-ray diffraction | A, B | YDZ | — |
| 5M84 | Translation initiation factor 4E in complex with (sp)-M2(7,2'O)GPPSPA mRNA 5' cap analog | x-ray diffraction | A, B | YDZ | — |
| 5OSX | Translation initiation factor 4E in complex with M7G(5'S)PPP(5'S)G mRNA 5' cap analog | x-ray diffraction | A, B, C, D | AKW, K | — |
| 6GKJ | Translation initiation factor 4E in complex with trinucleotide mRNA 5' cap (M7GPPPAPG) | x-ray diffraction | A, B, C, D | MGP | — |
| 6GKK | Translation initiation factor 4E in complex with beta-phosphorothioate trinucleotide mRNA 5' cap… | x-ray diffraction | A, B, C, D | WZO | — |
| 6GKL | Translation initiation factor 4E in complex with beta-phosphorothioate trinucleotide mRNA 5' cap… | x-ray diffraction | A, B, C, D | G0Z | — |
| 6U06 | Discovery of lysine-targeted EIF4E inhibitors through covalent docking | x-ray diffraction | A, B, C, D | EI8 | — |
| 6U09 | Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking | x-ray diffraction | A, B, C, D | EI9 | 5 (best 0.57) |
| 6U09 | Discovery of lysine-targeted EIF4E inhibitors through covalent docking | x-ray diffraction | A, B, C, D | EI9 | — |
| 6YLR | Translation initiation factor 4E in complex with BN7GPPPG mRNA 5' cap analog | x-ray diffraction | A, B | OYE | — |
| 6YLT | Translation initiation factor 4E in complex with 3-MEBN7GPPPG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | P3E | — |
| 6YLV | Translation initiation factor 4E in complex with 4-cl-BN7GPPPG mRNA 5' cap analog | x-ray diffraction | A, B, C, D | OYW | — |
| P63073 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P63073) | predicted | A | — | — |
Ligands
- 7L2 · [[[(3~{A}~{R},4~{R},6~{R},6~{A}~{R})-4-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-2,2-dimethyl-3~{A},4,6,6~{A}-tetrahydrofuro[3,4-D][1, 3]dioxol-6-yl]methoxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate · in 3 records
- WZO · [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-4-methoxy-3-oxidanyl-oxolan-2-yl]methyl [phosphonooxy(sulfanyl) phosphoryl] hydrogen phosphate · in 3 records
- EI9 · 3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl) methyl]sulfamoyl}benzene-1-sulfonyl fluoride · in 2 records
- YDZ · [[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl] [(2~{R},3~{R}, 4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanyl-purin-7-ium-9-yl)-4-methoxy-3-oxidanyl-oxolan-2-yl]methyl hydrogen phosphate · in 2 records
- 6G0 · 5'-O-[(R)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]-7-methylguanosine · in 1 record
- 6G6 · 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate · in 1 record
- 7LO · [[[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanyl-purin-7-ium-9-yl)-4-methoxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-selanyl-phosphoryl] [(2~{R},3~{S},4~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl) oxolan-2-yl]methyl hydrogen phosphate · in 1 record
- AKW · [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-3~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(3~{R}, 4~{S})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-phosphinic acid · in 1 record
- CL · Chloride ion · in 1 record
- EI8 · 3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride · in 1 record
- G0Z · [[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-4,5-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate · in 1 record
- K · Potassium ion · in 1 record
- MGP · 7-methyl-guanosine-5'-triphosphate · in 1 record
- OYE · Bn7gpppg mrna 5' cap analog · in 1 record
- OYW · 4-cl-bn7gpppg mrna 5' cap analog · in 1 record
- P3E · [[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-methylphenyl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl) oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate · in 1 record
- RSE · [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-4-methoxy-3-oxidanyl-oxolan-2-yl]methyl [phosphonooxy(selanyl) phosphoryl] hydrogen phosphate · in 1 record
Experiment against prediction
- 1L8B chain A against the predicted model P63073: TM-score 0.99, RMSD 0.51 Å
- 1L8B chain A against the predicted model P63073: TM-score 0.99, RMSD 0.51 Å
- 5M7W chain A against the predicted model P63073: TM-score 0.99, RMSD 0.56 Å
- 5BXV chain C against the predicted model P63073: TM-score 0.99, RMSD 0.60 Å
- 5M7W chain B against the predicted model P63073: TM-score 0.99, RMSD 0.60 Å
- 5M7Z chain D against the predicted model P63073: TM-score 0.99, RMSD 0.53 Å
- 5M7Z chain B against the predicted model P63073: TM-score 0.99, RMSD 0.64 Å
- 5OSX chain A against the predicted model P63073: TM-score 0.99, RMSD 0.61 Å
- 1EJH chain D against the predicted model P63073: TM-score 0.99, RMSD 0.54 Å
- 1EJH chain D against the predicted model P63073: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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