UniProt P62812
Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 (P62812)
Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 (UniProt P62812): 10 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 99…
- UniProt
- P62812
- Protein
- Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit…
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 99 · 6 records with a druggable one
Structures
11 records of P62812 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5OSA | GLIC-GABAAR alpha1 chimera crystallized at pH4.6 | x-ray diffraction | A, B, C, D, E | CL, D12, Y01 | 20 (best 0.78) |
| 5OSA | Glic-gabaar ALPHA1 chimera crystallized at PH4.6 | x-ray diffraction | A, B, C, D, E | CL, D12, Y01 | — |
| 5OSB | GLIC-GABAAR alpha1 chimera crystallized in complex with THDOC at pH4.5 | x-ray diffraction | A, B, C, D, E | A8Z, CL | 20 (best 0.78) |
| 5OSB | Glic-gabaar ALPHA1 chimera crystallized in complex with thdoc at PH4.5 | x-ray diffraction | A, B, C, D, E | A8Z, CL | — |
| 5OSC | Glic-gabaar ALPHA1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5 | x-ray diffraction | A, B, C, D, E | CL, A8W, Y01 | — |
| 8FOI | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and… | electron microscopy | A, C | NAG, MAN, PIO, D12, POV, ABU | 17 (best 0.82) |
| 8G4N | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA… | electron microscopy | A, C | NAG, MAN, Y4B, PIO, D12, POV | 17 (best 0.82) |
| 8G5F | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | C | NAG, ABU, Y4B, PIO | 12 (best 0.83) |
| 8G5G | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | A | NAG, PIO, Y4B, ABU | — |
| 8G5H | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | C | NAG, ABU, PIO, R5R | 13 (best 0.83) |
| P62812 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-1 (P62812) | predicted | A | — | — |
Ligands
- ABU · Gamma-amino-butanoic acid · in 5 records
- CL · Chloride ion · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 5 records
- D12 · Dodecane · in 4 records
- Y4B · allopregnanolone · in 4 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- A8Z · Tetrahydrodeoxycorticosterone · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- R5R · Zolpidem · in 2 records
- A8W · Pregnenolone sulfate · in 1 record
Experiment against prediction
- 8FOI chain A against the predicted model P62812: TM-score 0.98, RMSD 0.94 Å
- 8FOI chain C against the predicted model P62812: TM-score 0.98, RMSD 0.98 Å
- 8G4N chain A against the predicted model P62812: TM-score 0.98, RMSD 1.03 Å
- 8G4N chain C against the predicted model P62812: TM-score 0.98, RMSD 1.03 Å
- 8G5H chain C against the predicted model P62812: TM-score 0.97, RMSD 1.22 Å
- 8G5F chain C against the predicted model P62812: TM-score 0.96, RMSD 1.37 Å
- 5OSB chain A against the predicted model Q7NDN8: TM-score 0.95, RMSD 1.49 Å
- 5OSB chain A against the predicted model Q7NDN8: TM-score 0.95, RMSD 1.49 Å
- 5OSC chain A against the predicted model Q7NDN8: TM-score 0.95, RMSD 1.55 Å
- 5OSA chain D against the predicted model Q7NDN8: TM-score 0.95, RMSD 1.54 Å
Elsewhere
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