UniProt P60709
Actin, cytoplasmic 1, N-terminally processed (P60709)
Actin, cytoplasmic 1, N-terminally processed (UniProt P60709): 30 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P60709
- Protein
- Actin, cytoplasmic 1, N-terminally processed
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 36 · 4 records with a druggable one
Structures
31 records of P60709 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3D2U | Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor | x-ray diffraction | G, C | — | — |
| 3D2U | Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor | x-ray diffraction | G, C | — | — |
| 3J82 | Electron cryo-microscopy of DNGR-1 in complex with F-actin | electron microscopy | B, C, D | — | — |
| 3J82 | Electron cryo-microscopy of dngr-1 in complex with F-actin | electron microscopy | B, C, D | — | — |
| 3LUE | Model of alpha-actinin CH1 bound to F-actin | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 3LUE | Model of alpha-actinin CH1 bound to F-actin | electron microscopy | A, B, C, D, E, F, G, H, I, J | — | — |
| 6ANU | Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain | electron microscopy | F, A, B, C, D, E | — | — |
| 6ANU | Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain | electron microscopy | F, A, B, C, D, E | — | — |
| 6ICT | Structure of SETD3 bound to sah and methylated actin | x-ray diffraction | E, G, H, I | — | — |
| 6ICV | Structure of SETD3 bound to sah and unmodified actin | x-ray diffraction | C, D | — | — |
| 6LTJ | Structure of nucleosome-bound human baf complex | electron microscopy | K | — | — |
| 6MBJ | SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, P21 Crystal Form | x-ray diffraction | Y, Z | — | — |
| 6MBJ | SETD3, a histidine methyltransferase, in complex with an actin peptide and sah, P21 crystal form | x-ray diffraction | Y, Z | — | — |
| 6MBK | SETD3, a histidine methyltransferase, in complex with an actin peptide and sah, first P212121… | x-ray diffraction | Y, Z | — | — |
| 6MBL | SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second P212121… | x-ray diffraction | Y | — | — |
| 6MBL | SETD3, a histidine methyltransferase, in complex with an actin peptide and sah, second P212121… | x-ray diffraction | Y | — | — |
| 6NBW | Ternary complex of BETA/GAMMA-actin with profilin and ancoa-NAA80 | x-ray diffraction | A | CA, ATP, LAB | — |
| 6OX0 | SETD3 in Complex with an Actin Peptide with Sinefungin Replacing SAH as Cofactor | x-ray diffraction | Y, Z | — | — |
| 6OX0 | SETD3 in complex with an actin peptide with sinefungin replacing sah as cofactor | x-ray diffraction | Y, Z | — | — |
| 6OX1 | SETD3 in complex with an actin peptide with target histidine partially methylated | x-ray diffraction | Y, Z | — | — |
| 6OX2 | SETD3IN complex with an actin peptide with the target histidine fully methylated | x-ray diffraction | Y, Z | — | — |
| 6OX4 | A SETD3 mutant (N255A) in complex with an actin peptide | x-ray diffraction | Y, Z | — | — |
| 6OX5 | A SETD3 Mutant (N255A) in Complex with an Actin Peptide with His73 Replaced with Lysine | x-ray diffraction | Y | — | — |
| 6OX5 | A SETD3 mutant (N255A) in complex with an actin peptide with HIS73 replaced with lysine | x-ray diffraction | Y | — | — |
| 7P1H | Structure of the V. vulnificus exoy-G-actin-profilin complex | electron microscopy | B | CA, ATP | — |
| 7VDV | The overall structure of human chromatin remodeling pbaf-nucleosome complex | electron microscopy | P | — | — |
| 8QR1 | Cryo-EM structure of the human Tip60 complex | electron microscopy | B, G | — | 4 (best 0.88) |
| 8RTY | Structure of the F-actin barbed end bound by Cdc12 and profilin (ring complex) at a resolution of… | electron microscopy | A, B, C, D | ADP, MG, PO4 | 17 (best 0.86) |
| 8X15 | Structure of nucleosome-bound SRCAP-C in the apo state | electron microscopy | S, U | ATP | 3 (best 0.87) |
| 9FJM | Cryo-EM structure of the phalloidin-bound pointed end of the actin filament. | electron microscopy | A, B, C, D | ADP, MG, PO4 | 12 (best 0.86) |
| P60709 | AlphaFold monomer V2.0 prediction for actin, cytoplasmic 1 (P60709) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8X15 chain S against the predicted model P60709: TM-score 1.00, RMSD 0.27 Å
- 8QR1 chain G against the predicted model P60709: TM-score 0.99, RMSD 0.81 Å
- 6NBW chain A against the predicted model P60709: TM-score 0.99, RMSD 0.90 Å
- 8RTY chain D against the predicted model P60709: TM-score 0.97, RMSD 1.22 Å
- 6LTJ chain K against the predicted model P60709: TM-score 0.97, RMSD 1.20 Å
- 9FJM chain A against the predicted model P60709: TM-score 0.97, RMSD 1.25 Å
- 7VDV chain P against the predicted model P60709: TM-score 0.97, RMSD 1.23 Å
- 8RTY chain C against the predicted model P60709: TM-score 0.97, RMSD 1.37 Å
- 9FJM chain B against the predicted model P60709: TM-score 0.96, RMSD 1.37 Å
- 8RTY chain B against the predicted model P60709: TM-score 0.96, RMSD 1.42 Å
Elsewhere
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