UniProt P57764
Gasdermin-D (P57764)
Gasdermin-D (UniProt P57764): 11 experimental structures and 1 predicted model on GenesisL1, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P57764
- Protein
- Gasdermin-D
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 24 · 1 record with a druggable one
Structures
12 records of P57764 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5NH1 | Structure of the C-terminal domain of human Gasdermin D | x-ray diffraction | A | — | 2 (best 0.39) |
| 5NH1 | Structure of the C-terminal domain of human gasdermin D | x-ray diffraction | A | — | — |
| 5WQT | Structure of a protein involved in pyroptosis | x-ray diffraction | A, B | — | 6 (best 0.37) |
| 5WQT | Structure of a protein involved in pyroptosis | x-ray diffraction | A, B | — | — |
| 6AO4 | Crystal structure of the human gasdermin D C-terminal domain | x-ray diffraction | A | — | — |
| 6KMZ | Caspase-4 P22/P10 C258A in complex with human gsdmd-C domain | x-ray diffraction | E, H | — | — |
| 6KN0 | Caspase-1 P20/P10 C285A in complex with human gsdmd-C domain | x-ray diffraction | E, F | — | — |
| 6N9O | Crystal structure of human GSDMD | x-ray diffraction | A, B, C, D | — | — |
| 6N9O | Crystal structure of human gsdmd | x-ray diffraction | A, B, C, D | — | — |
| 6VFE | Gasdermin D pore | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g | — | — |
| 7Z1X | Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6 | x-ray diffraction | A, D | — | 16 (best 0.81) |
| P57764 | AlphaFold monomer V2.0 prediction for gasdermin-D (P57764) | predicted | A | — | — |
Experiment against prediction
- 6KN0 chain F against the predicted model P57764: TM-score 0.98, RMSD 0.75 Å
- 6KN0 chain E against the predicted model P57764: TM-score 0.98, RMSD 0.88 Å
- 6N9O chain C against the predicted model P57764: TM-score 0.95, RMSD 1.73 Å
- 6N9O chain C against the predicted model P57764: TM-score 0.95, RMSD 1.73 Å
- 6N9O chain B against the predicted model P57764: TM-score 0.95, RMSD 1.69 Å
- 6N9O chain B against the predicted model P57764: TM-score 0.95, RMSD 1.69 Å
- 6AO4 chain A against the predicted model P57764: TM-score 0.95, RMSD 1.32 Å
- 6KMZ chain E against the predicted model P57764: TM-score 0.94, RMSD 1.27 Å
- 6N9O chain A against the predicted model P57764: TM-score 0.94, RMSD 1.83 Å
- 6N9O chain A against the predicted model P57764: TM-score 0.94, RMSD 1.83 Å
Elsewhere
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