MolNFT v1 · #143060 · protein

Crystal structure of the human gasdermin D C-terminal domain

6AO4 · Gasdermin-D: “Crystal structure of the human gasdermin D C-terminal domain”. X-ray diffraction, 1 pocket (best druggability 0.42). MolNFT v1 #143060 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AO4
Type: protein
Length: 192 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gasdermin-D
UniProt: P57764
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 61% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gasdermin-D	protein	192	61% helix, 4% strand	P57764

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.42	0.78	21	empty

Compared structures

6AO4 · Crystal structure of the human gasdermin D C-terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
P57764 · AlphaFold monomer V2.0 prediction for gasdermin-D (P57764) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P57764
Elsewhere: RCSB PDB 6AO4 · PDBe 6AO4 · UniProt P57764

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