MolNFT v1 · #128117 · protein

Structure of the C-terminal domain of human gasdermin D

5NH1 · Gasdermin-D: “Structure of the C-terminal domain of human gasdermin D”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #128117 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5NH1
Type: protein
Length: 199 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gasdermin-D
UniProt: P57764
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gasdermin-D	protein	199	60% helix, 5% strand	P57764

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.39	0.79	13	empty
2	66	0.32	0.75	13	empty

Compared structures

5NH1 · Structure of the C-terminal domain of human Gasdermin D · the same entry in another collection · chain A against A, TM-score 1.00
P57764 · AlphaFold monomer V2.0 prediction for gasdermin-D (P57764) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P57764
Elsewhere: RCSB PDB 5NH1 · PDBe 5NH1 · UniProt P57764

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