UniProt P56874
Acid-activated urea channel (P56874)
Acid-activated urea channel (UniProt P56874): 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P56874
- Protein
- Acid-activated urea channel
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 37 · 3 records with a druggable one
Structures
7 records of P56874 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UX4 | Crystal structure of the urea channel from the human gastric pathogen Helicobacter pylori | x-ray diffraction | A, B, C | — | — |
| 3UX4 | Crystal structure of the urea channel from the human gastric pathogen helicobacter pylori | x-ray diffraction | A, B, C | — | — |
| 6NSJ | CryoEM structure of Helicobacter pylori urea channel in closed state | electron microscopy | A, B, C, D, E, F | XP4 | 15 (best 0.79) |
| 6NSJ | Cryoem structure of helicobacter pylori urea channel in closed state | electron microscopy | A, B, C, D, E, F | XP4 | — |
| 6NSK | CryoEM structure of Helicobacter pylori urea channel in open state. | electron microscopy | A, B, C, D, E, F | XP4 | 20 (best 0.70) |
| 6NSK | Cryoem structure of helicobacter pylori urea channel in open state. | electron microscopy | A, B, C, D, E, F | XP4 | — |
| P56874 | AlphaFold monomer V2.0 prediction for acid-activated urea channel (P56874) | predicted | A | — | 2 (best 0.71) |
Ligands
- XP4 · 1,2-dimyristoyl-sn-glycero-3-phosphate · in 4 records
Experiment against prediction
- 6NSK chain B against the predicted model P56874: TM-score 0.97, RMSD 0.94 Å
- 6NSK chain E against the predicted model P56874: TM-score 0.97, RMSD 0.94 Å
- 6NSK chain D against the predicted model P56874: TM-score 0.97, RMSD 0.95 Å
- 6NSK chain A against the predicted model P56874: TM-score 0.97, RMSD 0.95 Å
- 6NSK chain A against the predicted model P56874: TM-score 0.97, RMSD 0.95 Å
- 6NSK chain C against the predicted model P56874: TM-score 0.97, RMSD 0.95 Å
- 6NSK chain F against the predicted model P56874: TM-score 0.97, RMSD 0.95 Å
- 6NSJ chain C against the predicted model P56874: TM-score 0.94, RMSD 1.81 Å
- 6NSJ chain F against the predicted model P56874: TM-score 0.94, RMSD 1.81 Å
- 6NSJ chain D against the predicted model P56874: TM-score 0.94, RMSD 1.81 Å
Elsewhere
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