MolNFT v1 · #81635 · protein
Crystal structure of the urea channel from the human gastric pathogen helicobacter pylori
3UX4 · Acid-activated urea channel: “Crystal structure of the urea channel from the human gastric pathogen helicobacter pylori”. X-ray diffraction, 1 ligand (XP4), 10 pockets (best druggability 0.70). MolNFT v1 #81635 on GenesisL1: 3D…
- PDB
- 3UX4
- Type
- protein
- Length
- 540 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acid-activated urea channel
- UniProt
- P56874
- Ligands
- XP4
- Pockets
- 10 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Acid-activated urea channel | protein | 180 | 73% helix, 0% strand | P56874 |
Ligands and binding sites
- XP4 · 1,2-dimyristoyl-sn-glycero-3-phosphate · ligand · 9 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 346 | 0.70 | 0.83 | 29 | empty |
| 2 | 330 | 0.69 | 0.82 | 29 | empty |
| 3 | 320 | 0.69 | 0.83 | 28 | empty |
| 4 | 408 | 0.66 | 0.79 | 52 | empty |
| 5 | 422 | 0.65 | 0.78 | 48 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1376 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 1374 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3UX4 · Crystal structure of the urea channel from the human gastric pathogen Helicobacter pylori · the same entry in another collection · chain A against A, TM-score 1.00
- P56874 · AlphaFold monomer V2.0 prediction for acid-activated urea channel (P56874) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56874
- Elsewhere: RCSB PDB 3UX4 · PDBe 3UX4 · UniProt P56874
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.