UniProt P56726
Smoothened homolog (P56726)
Smoothened homolog (UniProt P56726): 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P56726
- Protein
- Smoothened homolog
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 7 · 1 record with a druggable one
Structures
5 records of P56726 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6O3C | Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 | x-ray diffraction | A | PO4, NA, OLB, NAG, LKD, CLR | — |
| 6O3C | Crystal structure of active smoothened bound to SAG21K, cholesterol, and NBSMO8 | x-ray diffraction | A | PO4, NA, OLB, NAG, LKD, CLR | — |
| 8CXO | Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment | electron microscopy | A | CLR | — |
| 8CXO | Cryo-EM structure of the unliganded msmo-PGS2 in a lipidic environment | electron microscopy | A | CLR | — |
| P56726 | AlphaFold monomer V2.0 prediction for smoothened homolog (P56726) | predicted | A | — | 7 (best 0.81) |
Ligands
- CLR · Cholesterol · in 4 records
- LKD · 3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl) phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide · in 2 records
- NA · Sodium ion · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- OLB · (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · in 2 records
- PO4 · Phosphate ion · in 2 records
Experiment against prediction
- 6O3C chain A against the predicted model P56726: TM-score 0.96, RMSD 1.78 Å
- 6O3C chain A against the predicted model P56726: TM-score 0.96, RMSD 1.78 Å
- 8CXO chain A against the predicted model P56726: TM-score 0.62, RMSD 1.44 Å
- 8CXO chain A against the predicted model P56726: TM-score 0.62, RMSD 1.44 Å
Elsewhere
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