UniProt P55097
Cathepsin K (P55097)
Cathepsin K (UniProt P55097), EC 3.4.22.38: 5 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P55097
- Protein
- Cathepsin K
- EC
- 3.4.22.38
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 5 · 2 records with a druggable one
Structures
6 records of P55097 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5T6U | Crystal structure of mouse cathepsin K at 2.9 Angstroms resolution. | x-ray diffraction | A | SO4, NAG | — |
| 5T6U | Crystal structure of mouse cathepsin K at 2.9 ångströms resolution. | x-ray diffraction | A | SO4, NAG | — |
| 6BKI | Crystal structure of T101A variant mouse cathepsin K at 2.94 ångström resolution. | x-ray diffraction | A, B | SO4 | — |
| 8V57 | Complex of murine cathepsin K with bound cystatin C inhibitor | x-ray diffraction | A, B | NAG, SO4 | 4 (best 0.65) |
| 8V58 | Complex of murine cathepsin K with bound heparan sulfate 12mer | x-ray diffraction | A, B | NAG, GAL, FUC, IDS, SGN | 1 (best 0.56) |
| P55097 | AlphaFold monomer V2.0 prediction for cathepsin K (P55097) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- SO4 · Sulfate ion · in 4 records
- FUC · alpha-L-fucopyranose · in 1 record
- GAL · beta-D-galactopyranose · in 1 record
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 1 record
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 1 record
Experiment against prediction
- 8V57 chain B against the predicted model P55097: TM-score 1.00, RMSD 0.36 Å
- 6BKI chain B against the predicted model P55097: TM-score 1.00, RMSD 0.37 Å
- 6BKI chain A against the predicted model P55097: TM-score 1.00, RMSD 0.37 Å
- 8V58 chain A against the predicted model P55097: TM-score 1.00, RMSD 0.37 Å
- 5T6U chain A against the predicted model P55097: TM-score 1.00, RMSD 0.38 Å
- 5T6U chain A against the predicted model P55097: TM-score 1.00, RMSD 0.38 Å
- 8V57 chain A against the predicted model P55097: TM-score 0.99, RMSD 0.40 Å
- 8V58 chain B against the predicted model P55097: TM-score 0.99, RMSD 0.44 Å
Elsewhere
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