UniProt P51570
Galactokinase (P51570)
Galactokinase (UniProt P51570), EC 2.7.1.6: 24 experimental structures and 1 predicted model on GenesisL1, 23 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P51570
- Protein
- Galactokinase
- EC
- 2.7.1.6
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 23
- Pockets
- 24 · 2 records with a druggable one
Structures
25 records of P51570 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WUU | crystal structure of human galactokinase complexed with MgAMPPNP and galactose | x-ray diffraction | A, B, C, D | — | — |
| 1WUU | Crystal structure of human galactokinase complexed with mgamppnp and galactose | x-ray diffraction | A, B, C, D | — | — |
| 6GR2 | Structure of human galactokinase in complex with galactose and ADP | x-ray diffraction | A, B, C, D, E, F, G, H | GAL, ADP, SO4 | — |
| 6Q3W | Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate | x-ray diffraction | A, B, C, D | GAL, HFK, HGE | 16 (best 0.83) |
| 6Q3W | Structure of human galactokinase 1 bound with ethyl 1-(2-pyrazinyl)-4- piperidinecarboxylate | x-ray diffraction | A, B, C, D | GAL, HFK, HGE | — |
| 6Q3X | Structure of human galactokinase in complex with galactose and 2'… | x-ray diffraction | A, B | GAL, HFK | — |
| 6Q8Z | Structure of human galactokinase 1 bound with N-(cyclobutylmethyl)-1… | x-ray diffraction | A, B, C, D | GAL, HFK, HR5 | — |
| 6Q90 | Structure of human galactokinase 1 bound with 1-(4-methoxyphenyl)-3- (4-PYRIDINYL)UREA | x-ray diffraction | A, B, C, D | GAL, HFK, JHJ | — |
| 6Q91 | Structure of human galactokinase 1 bound with 5-chloro-N-isobutyl-2- methoxybenzamide | x-ray diffraction | A, B, C, D | GAL, HFK, HR8 | — |
| 6QJE | Structure of human galactokinase 1 bound with 4-{[2-(methylsulfonyl)… | x-ray diffraction | A, B, C, D | GAL, HFK, J4Q, SO4 | — |
| 6ZFH | Structure of human galactokinase in complex with galactose and 2'… | x-ray diffraction | A, B, C, D, E, F, G, H | GAL, QV2 | — |
| 6ZGV | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N- (pyrimidin-2-YL)ACETAMIDE | x-ray diffraction | A, B, E, D | GAL, HFK, QKZ | — |
| 6ZGW | Structure of human galactokinase 1 bound with (4-CHLOROPHENYL)METHYL pyridine-3-carboxylate | x-ray diffraction | A, B, E, D | GAL, HFK, QKW | — |
| 6ZGX | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N- (pyrimidin-2-YL)ACETAMIDE | x-ray diffraction | A, B, D, E | GAL, HFK, S6V | — |
| 6ZGY | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N- (pyrimidin-2-YL)ACETAMIDE | x-ray diffraction | A, B, E, D | GAL, HFK, QL5 | — |
| 6ZGZ | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N- (pyrimidin-2-YL)ACETAMIDE | x-ray diffraction | A, B, E, D | GAL, HFK, SSY | — |
| 6ZH0 | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N- (pyrimidin-2-YL)ACETAMIDE | x-ray diffraction | A, B, E, D | GAL, HFK, WNP | — |
| 7OZX | Structure of human galactokinase 1 bound with azepan-1-YL(2,6- DIFLUOROPHENYL)METHANONE | x-ray diffraction | A, B, C, D | GAL, HFK, WLJ | — |
| 7RCL | Crystal structure of ADP-bound galactokinase | x-ray diffraction | A, B, C, D | GLA, ADP, PO4, MG, NA | — |
| 7RCM | Crystal structure of ADP-bound galactokinase | x-ray diffraction | A, B | ADP, GLA, PO4, MG, NA | — |
| 7S49 | Crystal Structure of Inhibitor-bound Galactokinase | x-ray diffraction | A, B | GLA, 4QI, PO4, NA | 8 (best 0.79) |
| 7S49 | Crystal structure of inhibitor-bound galactokinase | x-ray diffraction | A, B | GLA, 4QI, PO4, NA | — |
| 7S4C | Crystal Structure of Inhibitor-bound Galactokinase | x-ray diffraction | A, B | GLA, V3V, NA, PO4 | — |
| 7S4C | Crystal structure of inhibitor-bound galactokinase | x-ray diffraction | A, B | GLA, V3V, NA, PO4 | — |
| P51570 | AlphaFold monomer V2.0 prediction for galactokinase (P51570) | predicted | A | — | — |
Ligands
- GAL · beta-D-galactopyranose · in 16 records
- HFK · 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one · in 14 records
- GLA · alpha-D-galactopyranose · in 6 records
- NA · Sodium ion · in 6 records
- PO4 · Phosphate ion · in 6 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- 4QI · (4R)-2-[(1,3-benzoxazol-2-yl)amino]-4-(4-chloro-1H-pyrazol-5-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one · in 2 records
- HGE · ethyl 1-pyrazin-2-ylpiperidine-4-carboxylate · in 2 records
- MG · Magnesium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- V3V · 2-({(4R)-4-(2-chlorophenyl)-2-[(6-fluoro-1,3-benzoxazol-2-yl)amino]-6-methyl-1,4-dihydropyrimidine-5-carbonyl}amino)pyridine-4-carboxylic acid · in 2 records
- HR5 · ~{N}-(cyclobutylmethyl)-1,5-dimethyl-pyrazole-4-carboxamide · in 1 record
- HR8 · 5-chloranyl-2-methoxy-~{N}-(2-methylpropyl)benzamide · in 1 record
- J4Q · 4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole · in 1 record
- JHJ · N-(4-methoxyphenyl)-N'-pyridin-4-ylurea · in 1 record
- QKW · (4-chlorophenyl)methyl pyridine-3-carboxylate · in 1 record
- QKZ · 2-(4-chlorophenyl)-~{N}-pyrimidin-2-yl-ethanamide · in 1 record
- QL5 · (2,5-dimethylphenyl) pyridine-4-carboxylate · in 1 record
- QV2 · 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]-5-one · in 1 record
- S6V · 1-[2-(2-oxidanylidenepyrrolidin-1-yl)ethyl]-3-phenyl-urea · in 1 record
- SSY · ~{N}-(3-ethanoylphenyl)-2,2,2-tris(fluoranyl)ethanamide · in 1 record
- WLJ · (azepan-1-yl)(2,6-difluorophenyl)methanone · in 1 record
- WNP · N-(3-chlorophenyl)-2,2,2-trifluoroacetamide · in 1 record
Experiment against prediction
- 6Q3W chain A against the predicted model P51570: TM-score 1.00, RMSD 0.31 Å
- 6Q3W chain A against the predicted model P51570: TM-score 1.00, RMSD 0.31 Å
- 6ZGZ chain E against the predicted model P51570: TM-score 1.00, RMSD 0.32 Å
- 6QJE chain A against the predicted model P51570: TM-score 1.00, RMSD 0.33 Å
- 6ZGW chain E against the predicted model P51570: TM-score 1.00, RMSD 0.33 Å
- 6ZGY chain E against the predicted model P51570: TM-score 1.00, RMSD 0.33 Å
- 7OZX chain A against the predicted model P51570: TM-score 1.00, RMSD 0.33 Å
- 6ZGV chain E against the predicted model P51570: TM-score 1.00, RMSD 0.34 Å
- 6Q90 chain A against the predicted model P51570: TM-score 1.00, RMSD 0.34 Å
- 6ZGX chain E against the predicted model P51570: TM-score 1.00, RMSD 0.34 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.