UniProt P51160
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (P51160)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (UniProt P51160), EC 3.1.4.35: 10 experimental structures on GenesisL1, 5 ligands bound, 62 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P51160
- Protein
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
- EC
- 3.1.4.35
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 62 · 4 records with a druggable one
Structures
10 records of P51160 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JWQ | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil | x-ray diffraction | A, B, C, D | — | — |
| 3JWQ | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil | x-ray diffraction | A, B, C, D | — | — |
| 3JWR | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine… | x-ray diffraction | A, B | — | — |
| 3JWR | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine… | x-ray diffraction | A, B | — | — |
| 5E8F | Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D | x-ray diffraction | D, E | GER | 2 (best 0.86) |
| 5E8F | Structure of fully modified geranylgeranylated PDE6C peptide in complex with PDE6D | x-ray diffraction | D, E | — | — |
| 9CXG | Structure of PDE6C in complex with inhibitory cone p gamma in the presence of cGMP | electron microscopy | A, B | PCG, ZN, MG, 5GP | 20 (best 0.86) |
| 9CXH | Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the presence of cGMP | electron microscopy | A, B | PCG, ZN, MG, 5GP | 20 (best 0.85) |
| 9CXI | Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the absence of added cGMP | electron microscopy | A, B | ZN, MG, PCG | 20 (best 0.84) |
| P51160 | AlphaFold monomer V2.0 prediction for cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit… | — | — | — |
Ligands
Elsewhere
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