UniProt P51149
Ras-related protein Rab-7a (P51149)
Ras-related protein Rab-7a (UniProt P51149), EC 3.6.5.2: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P51149
- Protein
- Ras-related protein Rab-7a
- EC
- 3.6.5.2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 6 · 1 record with a druggable one
Structures
11 records of P51149 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T91 | crystal structure of human small GTPase Rab7(GTP) | x-ray diffraction | A, B, C, D | — | — |
| 1T91 | Crystal structure of human small GTPase RAB7(GTP) | x-ray diffraction | A, B, C, D | — | — |
| 1YHN | Structure basis of RILP recruitment by Rab7 | x-ray diffraction | A | — | — |
| 1YHN | Structure basis of rilp recruitment by RAB7 | x-ray diffraction | A | — | — |
| 3LAW | Structure of GTP-bound L129F mutant Rab7 | x-ray diffraction | A, B, C, D, E | — | — |
| 3LAW | Structure of GTP-bound L129F mutant RAB7 | x-ray diffraction | A, B, C, D, E | — | — |
| 6IYB | Structure of human ORP1 ank - RAB7 complex | x-ray diffraction | A, C | MG, GTP | — |
| 6WCW | Structure of human rubicon rh domain in complex with GTP-bound RAB7 | x-ray diffraction | B | GTP, MG | — |
| 7F6J | Crystal structure of the PDZD8 coiled-coil domain - RAB7 complex | x-ray diffraction | A, B | MG, GTP | — |
| 8ZQ3 | Structure of ORP1L-RAB7A in the presence of GDP | x-ray diffraction | A | GDP | 3 (best 0.39) |
| P51149 | AlphaFold monomer V2.0 prediction for RAS-related protein rab-7A (P51149) | predicted | A | — | 3 (best 0.52) |
Ligands
Experiment against prediction
- 6IYB chain A against the predicted model P51149: TM-score 0.98, RMSD 0.70 Å
- 1T91 chain A against the predicted model P51149: TM-score 0.98, RMSD 0.83 Å
- 1T91 chain A against the predicted model P51149: TM-score 0.98, RMSD 0.83 Å
- 3LAW chain C against the predicted model P51149: TM-score 0.98, RMSD 0.93 Å
- 3LAW chain C against the predicted model P51149: TM-score 0.98, RMSD 0.93 Å
- 3LAW chain D against the predicted model P51149: TM-score 0.98, RMSD 0.91 Å
- 3LAW chain D against the predicted model P51149: TM-score 0.98, RMSD 0.91 Å
- 3LAW chain B against the predicted model P51149: TM-score 0.97, RMSD 1.02 Å
- 3LAW chain B against the predicted model P51149: TM-score 0.97, RMSD 1.02 Å
- 3LAW chain A against the predicted model P51149: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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