UniProt P50135
Histamine N-methyltransferase (P50135)
Histamine N-methyltransferase (UniProt P50135): 14 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P50135
- Protein
- Histamine N-methyltransferase
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
15 records of P50135 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JQD | Crystal Structure Analysis of Human Histamine Methyltransferase (Thr105 Polymorphic Variant)… | x-ray diffraction | A, B | — | — |
| 1JQD | Crystal structure analysis of human histamine methyltransferase (THR105 polymorphic variant)… | x-ray diffraction | A, B | — | — |
| 1JQE | Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant)… | x-ray diffraction | A, B | — | — |
| 1JQE | Crystal structure analysis of human histamine methyltransferase (ILE105 polymorphic variant)… | x-ray diffraction | A, B | — | — |
| 2AOT | Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine | x-ray diffraction | A, B | — | — |
| 2AOT | Histamine methyltransferase complexed with the antihistamine drug diphenhydramine | x-ray diffraction | A, B | — | — |
| 2AOU | Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine | x-ray diffraction | A, B | — | — |
| 2AOU | Histamine methyltransferase complexed with the antimalarial drug amodiaquine | x-ray diffraction | A, B | — | — |
| 2AOV | Histamine Methyltransferase Complexed with the Antifolate Drug Metoprine | x-ray diffraction | A, B | — | — |
| 2AOV | Histamine methyltransferase complexed with the antifolate drug metoprine | x-ray diffraction | A, B | — | — |
| 2AOW | Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase… | x-ray diffraction | A, B | — | — |
| 2AOW | Histamine methyltransferase (natural variant I105) complexed with the acetylcholinesterase… | x-ray diffraction | A, B | — | — |
| 2AOX | Histamine Methyltransferase (Primary Variant T105) Complexed with the Acetylcholinesterase… | x-ray diffraction | A, B | — | — |
| 2AOX | Histamine methyltransferase (primary variant T105) complexed with the acetylcholinesterase… | x-ray diffraction | A, B | — | — |
| P50135 | AlphaFold monomer V2.0 prediction for histamine N-methyltransferase (P50135) | predicted | A | — | 1 (best 0.77) |
Experiment against prediction
- 1JQD chain B against the predicted model P50135: TM-score 0.99, RMSD 0.56 Å
- 1JQD chain B against the predicted model P50135: TM-score 0.99, RMSD 0.56 Å
- 2AOT chain A against the predicted model P50135: TM-score 0.99, RMSD 0.54 Å
- 2AOT chain A against the predicted model P50135: TM-score 0.99, RMSD 0.54 Å
- 2AOW chain A against the predicted model P50135: TM-score 0.99, RMSD 0.73 Å
- 2AOW chain A against the predicted model P50135: TM-score 0.99, RMSD 0.73 Å
- 2AOU chain A against the predicted model P50135: TM-score 0.99, RMSD 0.73 Å
- 2AOU chain A against the predicted model P50135: TM-score 0.99, RMSD 0.73 Å
- 2AOX chain A against the predicted model P50135: TM-score 0.99, RMSD 0.75 Å
- 2AOX chain A against the predicted model P50135: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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