UniProt P50098
Inosine-5'-monophosphate dehydrogenase (P50098)
Inosine-5'-monophosphate dehydrogenase (UniProt P50098), EC 1.1.1.205: 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P50098
- Protein
- Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 19 · 2 records with a druggable one
Structures
4 records of P50098 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6RFU | In cellulo crystallization of trypanosoma brucei imp dehydrogenase enables the identification of… | x-ray diffraction | A, B | ATP, 5GP | — |
| 8C51 | Trypanosoma brucei IMP dehydrogenase (cyto) crystallized in High Five cells revealing native… | x-ray diffraction | A, B | GDP, ATP, PO4 | 10 (best 0.69) |
| 8C53 | Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands… | x-ray diffraction | A, B | GDP, ATP, PO4 | 9 (best 0.70) |
| P50098 | AlphaFold monomer V2.0 prediction for inosine-5'-monophosphate dehydrogenase (P50098) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8C53 chain A against the predicted model P50098: TM-score 0.87, RMSD 3.49 Å
- 8C51 chain A against the predicted model P50098: TM-score 0.87, RMSD 3.52 Å
- 8C51 chain B against the predicted model P50098: TM-score 0.86, RMSD 3.64 Å
- 8C53 chain B against the predicted model P50098: TM-score 0.86, RMSD 3.57 Å
- 6RFU chain B against the predicted model P50098: TM-score 0.86, RMSD 3.56 Å
- 6RFU chain A against the predicted model P50098: TM-score 0.86, RMSD 3.57 Å
Elsewhere
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