UniProt P49810
Presenilin-2 (P49810)
Presenilin-2 (UniProt P49810), EC 3.4.23.-: 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49810
- Protein
- Presenilin-2
- EC
- 3.4.23.-
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 22 · 3 records with a druggable one
Structures
3 records of P49810 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Y5X | CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | electron microscopy | B | PC1 | 7 (best 0.70) |
| 7Y5Z | CryoEM structure of human PS2-containing gamma-secretase | electron microscopy | B | PC1 | 11 (best 0.71) |
| P49810 | AlphaFold monomer V2.0 prediction for presenilin-2 (P49810) | predicted | A | — | 4 (best 0.80) |
Ligands
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 2 records
Experiment against prediction
- 7Y5Z chain B against the predicted model P49810: TM-score 0.97, RMSD 0.89 Å
- 7Y5X chain B against the predicted model P49810: TM-score 0.97, RMSD 0.91 Å
Elsewhere
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