MolNFT v1 · #317197 · protein

AlphaFold monomer V2.0 prediction for presenilin-2 (P49810)

P49810: “AlphaFold monomer V2.0 prediction for presenilin-2 (P49810)”. 4 pockets (best druggability 0.80). MolNFT v1 #317197 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P49810
Type: protein
Length: 448 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x6DAA77C4263E74E745cA9c4D8E291e57e8991Cf5
Molecule: Presenilin-2
UniProt: P49810
Pockets: 4 · best druggability 0.80

Structure

1 distinct chain · 56% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Presenilin-2	protein	448	56% helix, 1% strand	P49810

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1104	0.80	0.81	70	empty
2	237	0.60	0.80	30	empty
3	185	0.57	0.81	25	empty
4	73	0.28	0.71	13	empty

Compared structures

7Y5X · CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 · an experimental structure of the same protein · chain A against B, TM-score 0.46
7Y5Z · CryoEM structure of human PS2-containing gamma-secretase · an experimental structure of the same protein · chain A against B, TM-score 0.46

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49810
Elsewhere: UniProt P49810 · AlphaFold DB P49810

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.