UniProt P49366
Deoxyhypusine synthase (P49366)
Deoxyhypusine synthase (UniProt P49366), EC 2.5.1.46: 33 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49366
- Protein
- Deoxyhypusine synthase
- EC
- 2.5.1.46
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 80 · 9 records with a druggable one
Structures
34 records of P49366 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DHS | Crystal structure of the NAD complex of human deoxyhypusine synthase | x-ray diffraction | A | — | — |
| 1DHS | Crystal structure of the NAD complex of human deoxyhypusine synthase | x-ray diffraction | A | — | — |
| 1RLZ | Deoxyhypusine synthase holoenzyme in its high ionic strength, low pH crystal form | x-ray diffraction | A | — | — |
| 1RLZ | Deoxyhypusine synthase holoenzyme in its high ionic strength, low pH crystal form | x-ray diffraction | A | — | — |
| 1ROZ | Deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form | x-ray diffraction | A, B | — | — |
| 1ROZ | Deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form | x-ray diffraction | A, B | — | — |
| 1RQD | deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the… | x-ray diffraction | A, B | — | — |
| 1RQD | Deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the… | x-ray diffraction | A, B | — | — |
| 6P4V | 1.65 ångström ternary complex of deoxyhypusine synthase with cofactor NAD and spermidine mimic… | x-ray diffraction | A, B | NAD, GC7 | — |
| 6PGR | Cocomplex structure of Deoxyhypusine synthase with inhibitor… | x-ray diffraction | A, B | 8XY | 7 (best 0.89) |
| 6PGR | Cocomplex structure of deoxyhypusine synthase with inhibitor 6-bromo… | x-ray diffraction | A, B | 8XY | — |
| 6WKZ | Cocomplex structure of Deoxyhypusine synthase with inhibitor… | x-ray diffraction | A, B | 8Y1 | 6 (best 0.88) |
| 6WKZ | Cocomplex structure of deoxyhypusine synthase with inhibitor 6-[(1R)… | x-ray diffraction | A, B | 8Y1 | — |
| 6WL6 | Cocomplex structure of Deoxyhypusine synthase with inhibitor… | x-ray diffraction | A, B | 91A | 6 (best 0.80) |
| 6WL6 | Cocomplex structure of deoxyhypusine synthase with inhibitor 6-[(2R)… | x-ray diffraction | A, B | 91A | — |
| 6XXH | Crystal Structure of Human Deoxyhypusine Synthase in apo form | x-ray diffraction | A, B | — | — |
| 6XXH | Crystal structure of human deoxyhypusine synthase in apo form | x-ray diffraction | A, B | — | — |
| 6XXI | Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD | x-ray diffraction | A, B | NAD | — |
| 6XXI | Crystal structure of human deoxyhypusine synthase in complex with NAD | x-ray diffraction | A, B | NAD | — |
| 6XXJ | Crystal structure of human deoxyhypusine synthase in complex with spermidine and NAD | x-ray diffraction | A, B | SPD, NAD, OXM | — |
| 6XXK | Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine | x-ray diffraction | A, B | SPD | — |
| 6XXK | Crystal structure of human deoxyhypusine synthase in complex with spermidine | x-ray diffraction | A, B | SPD | — |
| 6XXL | Crystal structure of human deoxyhypusine synthase in complex with spermine | x-ray diffraction | A, B | SPM, OXM | — |
| 6XXM | Crystal Structure of Human Deoxyhypusine Synthase in complex with putrescine | x-ray diffraction | A, B | PUT | — |
| 6XXM | Crystal structure of human deoxyhypusine synthase in complex with putrescine | x-ray diffraction | A, B | PUT | — |
| 7A6S | Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase | x-ray diffraction | A, B | OXM | 6 (best 0.86) |
| 7A6S | Crystal structure of ASN173SER variant of human deoxyhypusine synthase | x-ray diffraction | A, B | OXM | — |
| 7A6T | Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and… | x-ray diffraction | A, B | NAD, SPD, OXM | 8 (best 0.86) |
| 7A6T | Crystal structure of ASN173SER variant of human deoxyhypusine synthase in complex with NAD and… | x-ray diffraction | A, B | NAD, SPD, OXM | — |
| 8A0E | CryoEM structure of DHS-eIF5A1 complex | electron microscopy | A, B, C, D | NAD, SPD | 19 (best 0.91) |
| 8A0F | Crystal structure of human deoxyhypusine synthase variant K329A in complex with NAD and SPD | x-ray diffraction | A, B | SPD, NAD | 6 (best 0.87) |
| 8A0G | Human deoxyhypusine synthase with trapped transition state | x-ray diffraction | A, B | 13D, NAD, SPD | 6 (best 0.85) |
| 8R3U | Crystal structure of DHPS in complex with an inhibitor | x-ray diffraction | AAA, BBB, CCC, DDD | XTQ | 16 (best 0.88) |
| P49366 | AlphaFold monomer V2.0 prediction for deoxyhypusine synthase (P49366) | predicted | A | — | — |
Ligands
- NAD · Nicotinamide-adenine-dinucleotide · in 9 records
- SPD · Spermidine · in 8 records
- OXM · Oxamic acid · in 6 records
- 8XY · 6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide · in 2 records
- 8Y1 · 6-[(1R)-2-amino-1-phenylethyl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one · in 2 records
- 91A · 6-[(2R)-1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one · in 2 records
- PUT · 1,4-diaminobutane · in 2 records
- 13D · 1,3-diaminopropane · in 1 record
- GC7 · 1-guanidinium-7-aminoheptane · in 1 record
- SPM · Spermine · in 1 record
- XTQ · 2-[(2~{R})-1-azanyl-4-methyl-pentan-2-yl]-5-pyridin-3-yl-isoquinolin-1-one · in 1 record
Experiment against prediction
- 8A0F chain B against the predicted model P49366: TM-score 1.00, RMSD 0.37 Å
- 1ROZ chain B against the predicted model P49366: TM-score 1.00, RMSD 0.41 Å
- 1ROZ chain B against the predicted model P49366: TM-score 1.00, RMSD 0.41 Å
- 1RQD chain B against the predicted model P49366: TM-score 1.00, RMSD 0.44 Å
- 1RQD chain B against the predicted model P49366: TM-score 1.00, RMSD 0.44 Å
- 6P4V chain B against the predicted model P49366: TM-score 1.00, RMSD 0.46 Å
- 7A6T chain B against the predicted model P49366: TM-score 0.99, RMSD 0.51 Å
- 7A6T chain B against the predicted model P49366: TM-score 0.99, RMSD 0.51 Å
- 8A0G chain B against the predicted model P49366: TM-score 0.99, RMSD 0.54 Å
- 8A0F chain A against the predicted model P49366: TM-score 0.99, RMSD 0.58 Å
Elsewhere
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