UniProt P48775
Tryptophan 2,3-dioxygenase (P48775)
Tryptophan 2,3-dioxygenase (UniProt P48775), EC 1.13.11.11: 21 experimental structures on GenesisL1, 14 ligands bound, 220 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P48775
- Protein
- Tryptophan 2,3-dioxygenase
- EC
- 1.13.11.11
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 14
- Pockets
- 220 · 11 records with a druggable one
Structures
21 records of P48775 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4PW8 | Human tryptophan 2,3-dioxygenase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4PW8 | Human tryptophan 2,3-dioxygenase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5TI9 | Crystal structure of human tdo in complex with TRP and dioxygen, northeast structural genomics… | x-ray diffraction | A, B, C, D | OXY, HEM, PO4 | — |
| 5TIA | Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target… | x-ray diffraction | A, B, C, D | HEM, TRP | 20 (best 0.86) |
| 5TIA | Crystal structure of human tdo in complex with TRP, northeast structural genomics consortium target… | x-ray diffraction | A, B, C, D | HEM | — |
| 6A4I | Crystal Structure of human TDO inhibitor complex | x-ray diffraction | A, B, C, D | HEM, 9R9, TRP | 20 (best 0.87) |
| 6A4I | Crystal structure of human tdo inhibitor complex | x-ray diffraction | A, B, C, D | HEM, 9R9 | — |
| 6PYY | Crystal structure of human tryptophan 2,3-dioxygenase in complex with pf-06840003 in active site… | x-ray diffraction | A, B, C, D | HEM, H7S | — |
| 6PYZ | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in Active Site | x-ray diffraction | A, B, C, D | HEM, H7S, ZIQ | 20 (best 0.88) |
| 6PYZ | Crystal structure of human tryptophan 2,3-dioxygenase in complex with pf-06840003 in active site | x-ray diffraction | A, B, C, D | HEM, H7S | — |
| 6UD5 | Crystal structure of human tryptophan 2,3-dioxygenase in complex with carbon monoxide and tryptophan | x-ray diffraction | A, B, C, D | HEM, CMO, TRP | 20 (best 0.90) |
| 6UD5 | Crystal structure of human tryptophan 2,3-dioxygenase in complex with carbon monoxide and tryptophan | x-ray diffraction | A, B, C, D | HEM, CMO | — |
| 6VBN | Crystal structure of HTDO2 bound to inhibitor GNE1 | x-ray diffraction | A, B, C, D | HEM, QVY | — |
| 7LU7 | Human TDO (hTDO) in complex with NLG919 analog | x-ray diffraction | AAA, BBB, CCC, DDD | HEM, ZIQ, 5PK | 20 (best 0.85) |
| 8QV7 | Crystal structure of human TDO with alpha-methyl-L-tryptophan | x-ray diffraction | A, B, C, D | ZIQ | 20 (best 0.84) |
| 8R5Q | Structure of apo TDO with a bound inhibitor | x-ray diffraction | A, B, C, D | Y5N, ZIQ | 20 (best 0.83) |
| 8R5R | Structure of apo TDO with a bound inhibitor | x-ray diffraction | A, B, C, D | Y5N, ZIQ | 20 (best 0.84) |
| 8W1H | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN3 inhibitor | x-ray diffraction | A, B, C, D | HEM, ZIQ, A1AEY | 20 (best 0.82) |
| 9AT2 | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN3 inhibitor | x-ray diffraction | A, B, C, D | HEM, ZIQ, A1AF5 | 20 (best 0.83) |
| 9B1Q | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor | x-ray diffraction | A, B, C, D | HEM, A1AH8, ZIQ | 20 (best 0.79) |
| P48775 | AlphaFold monomer V2.0 prediction for tryptophan 2,3-dioxygenase (P48775) | — | — | — |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 15 records
- ZIQ · alpha-methyl-L-tryptophan · in 8 records
- H7S · (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione · in 3 records
- TRP · Tryptophan · in 3 records
- 9R9 · 1-(6-chloro-1H-indazol-4-yl)cyclohexan-1-ol · in 2 records
- CMO · Carbon monoxide · in 2 records
- Y5N · 3-chloranyl-~{N}-[(1~{S})-1-(6-chloranylpyridin-3-yl)-2-phenyl-ethyl]aniline · in 2 records
- 5PK · (1~{R})-1-cyclohexyl-2-[(5~{S})-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol · in 1 record
- A1AEY · (6M)-1-[(imidazolidin-1-yl)methyl]-6-(1H-indol-3-yl)-1H-benzotriazole · in 1 record
- A1AF5 · (6M)-6-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-1,2,3-benzotriazole · in 1 record
- A1AH8 · (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole · in 1 record
- OXY · Oxygen molecule · in 1 record
- PO4 · Phosphate ion · in 1 record
- QVY · 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.