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Ligand · ZIQ

ZIQ · alpha-methyl-L-tryptophan

ZIQ, alpha-methyl-L-tryptophan (C12 H14 N2 O2, 218.2 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
ZIQ
Formula
C12 H14 N2 O2
Class
ligand
Structures
10
PDB entries
10

Binding sites

ZIQ in 10 structures; the first of them:

  • 6PYZ · Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PF-06840003 in… · ZIQ A403 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 7LU7 · Human TDO (hTDO) in complex with NLG919 analog · ZIQ AAA402 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 8QV7 · Crystal structure of human TDO with alpha-methyl-L-tryptophan · ZIQ A401 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 4 more
  • 8R5Q · Structure of apo TDO with a bound inhibitor · ZIQ A502 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 8R5R · Structure of apo TDO with a bound inhibitor · ZIQ A502 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 8W1H · Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN3 inhibitor · ZIQ A402 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 8W2K · Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN3F inhibitor · ZIQ A402 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 9AT2 · Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN3 inhibitor · ZIQ A402 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 9B17 · Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN1 inhibitor · ZIQ A403 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more
  • 9B1Q · Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor · ZIQ A403 · binds VAL102, ARG103, GLU105, TRP208, ARG211, THR212, PRO213, ILE295 and 3 more

Residues it binds most

ARG 40, PRO 40, GLU 40, ILE 40, PHE 40, THR 40, TRP 40, VAL 40, HIS 4 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe
  • Y5N · 3-chloranyl-~{N}-[(1~{S})-1-(6-chloranylpyridin-3-yl)-2-phenyl-ethyl]aniline
  • 5PK · (1~{R})-1-cyclohexyl-2-[(5~{S})-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol
  • A1AE7 · (6M)-6-(6-fluoro-1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole
  • A1AEY · (6M)-1-[(imidazolidin-1-yl)methyl]-6-(1H-indol-3-yl)-1H-benzotriazole
  • A1AF5 · (6M)-6-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-1,2,3-benzotriazole
  • A1AH8 · (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole
  • A1AH9 · (5P)-5-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-1,2,3-benzotriazole
  • H7S · (3S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
  • GOL · Glycerol

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