UniProt P48356
Leptin receptor (P48356)
Leptin receptor (UniProt P48356): 9 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 71 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P48356
- Protein
- Leptin receptor
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 71 · 6 records with a druggable one
Structures
10 records of P48356 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Z3P | Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. | x-ray diffraction | B | CA | 1 (best 0.28) |
| 7Z3R | Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution. | x-ray diffraction | B | NAG | 1 (best 0.40) |
| 8AV2 | Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody… | x-ray diffraction | A, B | NAG, SO4 | 8 (best 0.79) |
| 8AVB | Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR… | electron microscopy | B, F | — | 12 (best 0.67) |
| 8AVD | Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local… | electron microscopy | B, D, F | NI | 17 (best 0.57) |
| 8B7Q | Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in… | electron microscopy | B, F | NAG | 1 (best 0.35) |
| 8DH8 | Leptin-bound leptin receptor complex-full ECD | electron microscopy | A, B | — | 15 (best 0.77) |
| 8DH9 | Leptin-bound leptin receptor complex-D3-D7 | electron microscopy | A, B | — | 12 (best 0.73) |
| 8DHA | Leptin-bound leptin receptor complex- focused interaction | electron microscopy | A, B | NAG | 4 (best 0.59) |
| P48356 | AlphaFold monomer V2.0 prediction for leptin receptor (P48356) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8DH8 chain B against the predicted model P48356: TM-score 1.00, RMSD 0.51 Å
- 8DH9 chain B against the predicted model P48356: TM-score 0.99, RMSD 0.80 Å
- 8B7Q chain F against the predicted model P48356: TM-score 0.97, RMSD 0.62 Å
- 8DH9 chain A against the predicted model P48356: TM-score 0.97, RMSD 1.47 Å
- 8B7Q chain B against the predicted model P48356: TM-score 0.97, RMSD 1.04 Å
- 8DHA chain B against the predicted model P48356: TM-score 0.97, RMSD 1.04 Å
- 8DH8 chain A against the predicted model P48356: TM-score 0.96, RMSD 1.90 Å
- 7Z3R chain B against the predicted model P48356: TM-score 0.95, RMSD 1.59 Å
- 7Z3P chain B against the predicted model P48356: TM-score 0.95, RMSD 1.29 Å
- 8DHA chain A against the predicted model P48356: TM-score 0.94, RMSD 0.87 Å
Elsewhere
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