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UniProt P48163

NADP-dependent malic enzyme (P48163)

NADP-dependent malic enzyme (UniProt P48163), EC 1.1.1.40: 9 experimental structures on GenesisL1, 3 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
P48163
Protein
NADP-dependent malic enzyme
EC
1.1.1.40
Experimental structures
9
Predicted models
0
Ligands
3
Pockets
40 · 2 records with a druggable one

Structures

9 records of P48163 in the MolNFT archive: 9 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
2AW5Crystal structure of a human malic enzymex-ray diffractionA, B, C——
2AW5Crystal structure of a human malic enzymex-ray diffractionA, B, C——
3WJAThe crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo formx-ray diffractionA, B——
3WJAThe crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo formx-ray diffractionA, B——
7X11Crystal structure of ME1 in complex with NADPHx-ray diffractionA, B, C, DMN, NDP, 86I20 (best 0.80)
7X11Crystal structure of ME1 in complex with NADPHx-ray diffractionA, B, C, DMN, NDP, 86I—
7X12Crystal structure of ME1 in complex with NADPHx-ray diffractionA, B, C, DMN, NDP20 (best 0.84)
7X12Crystal structure of ME1 in complex with NADPHx-ray diffractionA, B, C, DMN, NDP—
P48163AlphaFold monomer V2.0 prediction for NADP-dependent malic enzyme (P48163)———

Ligands

  • MN · Manganese (II) ion · in 4 records
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 4 records
  • 86I · 6-[(7-methyl-2-propyl-imidazo[4,5-b]pyridin-4-yl) methyl]-2-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]-1,3-benzothiazole · in 2 records

Elsewhere

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