UniProt P46977
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (P46977)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (UniProt P46977), EC 2.4.99.18: 4 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 38 pockets. Binding sites, druggability…
- UniProt
- P46977
- Protein
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- EC
- 2.4.99.18
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 38 · 4 records with a druggable one
Structures
5 records of P46977 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6S7O | Cryo-EM structure of human oligosaccharyltransferase complex OST-A | electron microscopy | A | NAG, KZB, EGY, MG, KZE | 15 (best 0.81) |
| 6S7O | Cryo-EM structure of human oligosaccharyltransferase complex ost-a | electron microscopy | A | NAG, KZB, EGY, MG, KZE | — |
| 8B6L | Subtomogram average of the human Sec61-TRAP-OSTA-translocon | electron microscopy | I | — | 5 (best 0.82) |
| 8PN9 | Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1 | electron microscopy | A | NAG, NDG, BMA, MAN, GLC, KZB | 14 (best 0.81) |
| P46977 | AlphaFold monomer V2.0 prediction for dolichyl- diphosphooligosaccharide--protein… | predicted | A | — | 4 (best 0.81) |
Ligands
- EGY · (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium · in 3 records
- KZB · (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S}, 9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13, 18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- KZE · [(3~{R},6~{Z},10~{Z},14~{Z},18~{Z})-3,7,11,15,19,23-hexamethyltetracosa-6,10,14,18,22-pentaenyl] dihydrogen phosphate · in 2 records
- MG · Magnesium ion · in 2 records
- BMA · beta-D-mannopyranose · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- MN · Manganese (II) ion · in 1 record
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · in 1 record
- OTP · (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaenyl trihydrogen diphosphate · in 1 record
- ZXT · 5-(dimethylsulfamoyl)-~{N}-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-yl-benzamide · in 1 record
Experiment against prediction
- 8PN9 chain A against the predicted model P46977: TM-score 0.99, RMSD 1.00 Å
- 8B6L chain I against the predicted model P46977: TM-score 0.99, RMSD 1.01 Å
- 6S7O chain A against the predicted model P46977: TM-score 0.99, RMSD 1.10 Å
- 6S7O chain A against the predicted model P46977: TM-score 0.99, RMSD 1.10 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.