UniProt P45983
Mitogen-activated protein kinase 8 (P45983)
Mitogen-activated protein kinase 8 (UniProt P45983), EC 2.7.11.24: 46 experimental structures on GenesisL1, 9 ligands bound, 54 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P45983
- Protein
- Mitogen-activated protein kinase 8
- EC
- 2.7.11.24
- Experimental structures
- 46
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 54 · 6 records with a druggable one
Structures
46 records of P45983 in the MolNFT archive: 46 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UKH | Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 | x-ray diffraction | A | — | — |
| 1UKH | Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 | x-ray diffraction | A | — | — |
| 1UKI | Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 | x-ray diffraction | A | — | — |
| 1UKI | Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 | x-ray diffraction | A | — | — |
| 2G01 | Pyrazoloquinolones as Novel, Selective JNK1 inhibitors | x-ray diffraction | A, B | — | — |
| 2G01 | Pyrazoloquinolones as novel, selective JNK1 inhibitors | x-ray diffraction | A, B | — | — |
| 2GMX | Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity | x-ray diffraction | A, B | — | — |
| 2GMX | Selective aminopyridine-based C-jun N-terminal kinase inhibitors with cellular activity | x-ray diffraction | A, B | — | — |
| 2H96 | Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun… | x-ray diffraction | A, B | — | — |
| 2H96 | Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide C-jun… | x-ray diffraction | A, B | — | — |
| 2NO3 | Novel 4-anilinopyrimidines as potent JNK1 Inhibitors | x-ray diffraction | A, B | — | — |
| 2NO3 | Novel 4-anilinopyrimidines as potent JNK1 inhibitors | x-ray diffraction | A, B | — | — |
| 2XS0 | Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of… | x-ray diffraction | A | — | — |
| 2XS0 | Linear binding motifs for jnk and for calcineurin antagonistically control the nuclear shuttling of… | x-ray diffraction | A | — | — |
| 3ELJ | Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor. | x-ray diffraction | A | — | — |
| 3ELJ | JNK1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor. | x-ray diffraction | A | — | — |
| 3O17 | Crystal Structure of JNK1-alpha1 isoform | x-ray diffraction | A, B | — | — |
| 3O17 | Crystal structure of JNK1-ALPHA1 isoform | x-ray diffraction | A, B | — | — |
| 3O2M | Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118) | x-ray diffraction | A, B | — | — |
| 3O2M | Crystal structure of JNK1-ALPHA1 isoform complex with a biaryl tetrazol (a-82118) | x-ray diffraction | A, B | — | — |
| 3PZE | JNK1 in complex with inhibitor | x-ray diffraction | A | — | — |
| 3PZE | JNK1 in complex with inhibitor | x-ray diffraction | A | — | — |
| 3V3V | Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor | x-ray diffraction | A | — | — |
| 3V3V | Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor | x-ray diffraction | A | — | — |
| 4AWI | Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor. | x-ray diffraction | A | — | — |
| 4AWI | Human JNK1ALPHA kinase with 4-phenyl-7-azaindole IKK2 inhibitor. | x-ray diffraction | A | — | — |
| 4E73 | Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor | x-ray diffraction | A | — | — |
| 4E73 | Crystal structure of JNK1BETA-jip in complex with an azaquinolone inhbitor | x-ray diffraction | A | — | — |
| 4L7F | Co-crystal Structure of JNK1 and AX13587 | x-ray diffraction | A | — | — |
| 4L7F | Co-crystal structure of JNK1 and AX13587 | x-ray diffraction | A | — | — |
| 4QTD | Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing… | x-ray diffraction | A | — | — |
| 4QTD | Structure of human JNK1 in complex with SCH772984 and the amppnp- hydrolysed triphosphate revealing… | x-ray diffraction | A | — | — |
| 4UX9 | Crystal structure of JNK1 bound to a MKK7 docking motif | x-ray diffraction | A, B, C, D | — | — |
| 4UX9 | Crystal structure of JNK1 bound to a MKK7 docking motif | x-ray diffraction | A, B, C, D | — | — |
| 4YR8 | Crystal structure of JNK in complex with a regulator protein | x-ray diffraction | E, A, C, F | — | — |
| 4YR8 | Crystal structure of jnk in complex with a regulator protein | x-ray diffraction | E, A, C, F | — | — |
| 5LW1 | Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1… | x-ray diffraction | B, E, H | SO4, ADN | 13 (best 0.88) |
| 5LW1 | Crystal structure of darpin-darpin rigid fusion, variant DD_232_11_D12 in complex JNK1A1 and JIP1… | x-ray diffraction | B, E, H | IVA, SO4, ADN | — |
| 6F5E | Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1… | x-ray diffraction | B | — | 7 (best 0.63) |
| 6F5E | Crystal structure of darpin-darpin rigid fusion, variant DD_D12_10_47 in complex JNK1A1 and JIP1… | x-ray diffraction | B | — | — |
| 6ZR5 | Crystal structure of JNK1 in complex with ATF2(19-58) | x-ray diffraction | A, B | MG, ANP | — |
| 8PT8 | JNK1 covalently bound to RU135 cyclohexe based inhibitor | x-ray diffraction | A, B, C | A3O | 14 (best 0.80) |
| 8PT9 | JNK1 covalently bound to BD838 cyclohexe based inhibitor | x-ray diffraction | A, B, C | DVI | 12 (best 0.74) |
| 8R5E | JNK1 covalently bound to RU77 cyclohexe based inhibitor | x-ray diffraction | A | MG, ANP, Y6K | 4 (best 0.76) |
| 8X5M | The Crystal Structure of JNK1 from Biortus. | x-ray diffraction | A | Y4O | 4 (best 0.57) |
| P45983 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 8 (P45983) | — | — | — |
Ligands
- ADN · Adenosine · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- MG · Magnesium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- A3O · methyl (1R,3R)-1-methyl-3-[[3-[[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methylcarbamoyl]-4-oxidanylidene-cyclohexane-1-carboxylate · in 1 record
- DVI · methyl (1S,3S)-1-methyl-3-[[3-[[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]carbamoyl]-4-oxidanylidene-cyclohexane-1-carboxylate · in 1 record
- IVA · Isovaleric acid · in 1 record
- Y4O · 3-[4-(dimethylamino)butanoylamino]-~{N}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide · in 1 record
- Y6K · ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{S},3~{R},5~{R})-6-methylidene-4-oxidanylidene-bicyclo[3.2.1]octane-1,3-dicarboxylate · in 1 record
Elsewhere
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