UniProt P41212
Transcription factor ETV6,Anthrax toxin receptor 2 (P41212)
Transcription factor ETV6,Anthrax toxin receptor 2 (UniProt P41212), EC 2.1.1.56, 2.7.10.2: 28 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 31 pockets. Binding sites, druggability and experiment…
- UniProt
- P41212
- Protein
- Transcription factor ETV6,Anthrax toxin receptor 2
- EC
- 2.1.1.56, 2.7.10.2, 2.7.11.1, 3.1.13.-
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 31 · 5 records with a druggable one
Structures
29 records of P41212 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JI7 | Crystal Structure of TEL SAM Polymer | x-ray diffraction | A, B, C | — | — |
| 1JI7 | Crystal structure of tel SAM polymer | x-ray diffraction | A, B, C | — | — |
| 1LKY | Structure of the wild-type TEL-SAM polymer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1LKY | Structure of the wild-type tel-SAM polymer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2DAO | Solution structure of ETS domain Transcriptional factor ETV6 protein | solution nmr | A | — | — |
| 2DAO | Solution structure of ets domain transcriptional factor ETV6 protein | solution nmr | A | — | — |
| 2QB0 | Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker. | x-ray diffraction | A, B, C, D | — | — |
| 5L0P | Symmetry-based assembly of a two-dimensional protein lattice | x-ray diffraction | A | — | — |
| 5L0P | Symmetry-based assembly of a two-dimensional protein lattice | x-ray diffraction | A | — | — |
| 7JU2 | Crystal structure of the monomeric ETV6 PNT domain | x-ray diffraction | A, B | — | — |
| 7JU2 | Crystal structure of the monomeric ETV6 pnt domain | x-ray diffraction | A, B | — | — |
| 7N1O | The von willebrand factor a domain of human capillary morphogenesis gene II, flexibly fused to the… | x-ray diffraction | A | MG, CL | — |
| 7N2B | A darpin semi-rigidly fused to the 3TEL crystallization chaperone | x-ray diffraction | A, B | — | — |
| 7TDY | The ubiquitin-associated domain of human thirty-eight negative kinase 1, flexibly fused to the 1TEL… | x-ray diffraction | A | — | — |
| 7U4W | The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL… | x-ray diffraction | A | — | — |
| 7U4Z | The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL… | x-ray diffraction | A | — | — |
| 8BWU | Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the SS148 inhibitor | x-ray diffraction | A | 6NR, ZN | 4 (best 0.45) |
| 8FRJ | Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946 | x-ray diffraction | A | ZN, AW2 | 3 (best 0.50) |
| 8FT8 | The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the… | x-ray diffraction | A | CL, K, SO4 | — |
| 8FZ3 | Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form | x-ray diffraction | A, B, C, D | CL, PO4 | 2 (best 0.74) |
| 8FZU | The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the… | x-ray diffraction | A, B, C | K, SO4 | 7 (best 0.66) |
| 8FZV | The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the… | x-ray diffraction | A, B, C | MG, UNX | 5 (best 0.82) |
| 9CPL | The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 2TEL… | x-ray diffraction | A | — | 1 (best 0.46) |
| 9DAM | A DARPin fused to the 1TEL crystallization chaperone via a direct helical fusion | x-ray diffraction | A | CL, MG, NA | 1 (best 0.57) |
| 9DB5 | A DARPin fused to the 1TEL crystallization chaperone via a proline-alanine linker | x-ray diffraction | A | NA, CL | 1 (best 0.27) |
| 9DP8 | A DARPin fused to the 1TEL crystallization chaperone via a helical Lys-Gln-Arg linker | x-ray diffraction | A | — | 2 (best 0.46) |
| 9DVG | A DARPin fused to the 1TEL crystallization chaperone via a direct helical fusion | x-ray diffraction | A | — | 2 (best 0.56) |
| 9FEH | Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor | x-ray diffraction | A | A1IB6, ZN | 3 (best 0.45) |
| P41212 | AlphaFold monomer V2.0 prediction for transcription factor ETV6 (P41212) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 5 records
- MG · Magnesium ion · in 3 records
- ZN · Zinc ion · in 3 records
- K · Potassium ion · in 2 records
- NA · Sodium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 6NR · (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid · in 1 record
- A1IB6 · ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide · in 1 record
- AW2 · 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl) carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
- PO4 · Phosphate ion · in 1 record
- UNX · Unknown atom or ion · in 1 record
Experiment against prediction
- 2QB0 chain C against the predicted model P41212: TM-score 0.98, RMSD 0.40 Å
- 2QB0 chain A against the predicted model P41212: TM-score 0.98, RMSD 0.40 Å
- 1LKY chain D against the predicted model P41212: TM-score 0.98, RMSD 0.48 Å
- 1LKY chain D against the predicted model P41212: TM-score 0.98, RMSD 0.48 Å
- 1LKY chain A against the predicted model P41212: TM-score 0.98, RMSD 0.49 Å
- 1LKY chain A against the predicted model P41212: TM-score 0.98, RMSD 0.49 Å
- 1LKY chain F against the predicted model P41212: TM-score 0.98, RMSD 0.52 Å
- 1LKY chain F against the predicted model P41212: TM-score 0.98, RMSD 0.52 Å
- 1JI7 chain B against the predicted model P41212: TM-score 0.97, RMSD 0.54 Å
- 1JI7 chain B against the predicted model P41212: TM-score 0.97, RMSD 0.54 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.