UniProt P40992
RNA polymerase I-specific transcription initiation factor RRN7 (P40992)
RNA polymerase I-specific transcription initiation factor RRN7 (UniProt P40992): 21 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 22 pockets. Binding sites, druggability and experiment against…
- UniProt
- P40992
- Protein
- RNA polymerase I-specific transcription initiation factor RRN7
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 22 · 4 records with a druggable one
Structures
22 records of P40992 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5N5Y | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III) | electron microscopy | Q | SO4, ZN | 4 (best 0.84) |
| 5N5Y | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation III) | electron microscopy | Q | SO4, ZN | — |
| 5N5Z | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation II) | electron microscopy | Q | ZN | 3 (best 0.84) |
| 5N5Z | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation II) | electron microscopy | Q | ZN | — |
| 5N60 | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation I) | electron microscopy | Q | ZN | — |
| 5N61 | RNA polymerase I initially transcribing complex | electron microscopy | Q | ZN | — |
| 5O7X | Crystal structure of S. cerevisiae core factor at 3.2A resolution | x-ray diffraction | B, E, H, K, N, Q | — | — |
| 5OA1 | RNA polymerase I pre-initiation complex | electron microscopy | U | — | — |
| 5W5Y | RNA polymerase I initial transcribing complex | electron microscopy | P | — | — |
| 5W64 | RNA polymerase I initial transcribing complex state 1 | electron microscopy | P | — | — |
| 5W65 | RNA polymerase I initial transcribing complex state 2 | electron microscopy | P | ZN | — |
| 5W66 | RNA polymerase I initial transcribing complex state 3 | electron microscopy | P | — | — |
| 6RQH | RNA Polymerase I Closed Conformation 1 (CC1) | electron microscopy | Q | — | — |
| 6RQH | RNA polymerase I closed conformation 1 (CC1) | electron microscopy | Q | — | — |
| 6RQL | RNA polymerase I closed conformation 2 (CC2) | electron microscopy | Q | — | — |
| 6RRD | RNA polymerase I pre-initiation complex DNA opening intermediate 1 | electron microscopy | Q | ZN | — |
| 6RUI | RNA polymerase I pre-initiation complex DNA opening intermediate 2 | electron microscopy | Q | ZN | — |
| 6RUO | RNA Polymerase I Open Complex conformation 1 | electron microscopy | Q | ZN | 4 (best 0.87) |
| 6RUO | RNA polymerase I open complex conformation 1 | electron microscopy | Q | ZN | — |
| 6RWE | RNA polymerase I open complex conformation 2 | electron microscopy | Q | ZN | — |
| 6TPS | Early intermediate RNA polymerase I pre-initiation complex - eipic | electron microscopy | Q | ZN | — |
| P40992 | AlphaFold monomer V2.0 prediction for RNA polymerase I-specific transcription initiation factor… | predicted | A | — | 11 (best 0.65) |
Ligands
Experiment against prediction
- 5O7X chain B against the predicted model P40992: TM-score 0.93, RMSD 2.25 Å
- 5W64 chain P against the predicted model P40992: TM-score 0.92, RMSD 2.43 Å
- 5W66 chain P against the predicted model P40992: TM-score 0.92, RMSD 2.45 Å
- 5W5Y chain P against the predicted model P40992: TM-score 0.92, RMSD 2.46 Å
- 5N5Y chain Q against the predicted model P40992: TM-score 0.86, RMSD 2.16 Å
- 5N5Y chain Q against the predicted model P40992: TM-score 0.86, RMSD 2.16 Å
- 5N60 chain Q against the predicted model P40992: TM-score 0.86, RMSD 2.29 Å
- 5N61 chain Q against the predicted model P40992: TM-score 0.85, RMSD 2.20 Å
- 5N5Z chain Q against the predicted model P40992: TM-score 0.85, RMSD 2.46 Å
- 5N5Z chain Q against the predicted model P40992: TM-score 0.85, RMSD 2.46 Å
Elsewhere
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