UniProt P40318
ERAD-associated E3 ubiquitin-protein ligase DOA10 (P40318)
ERAD-associated E3 ubiquitin-protein ligase DOA10 (UniProt P40318), EC 2.3.2.27: 5 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 30 pockets. Binding sites, druggability and experiment against…
- UniProt
- P40318
- Protein
- ERAD-associated E3 ubiquitin-protein ligase DOA10
- EC
- 2.3.2.27
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 30 · 3 records with a druggable one
Structures
6 records of P40318 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2M6M | Solution structure of RING domain of E3 ubiquitin ligase Doa10 | solution nmr | A | — | — |
| 2M6M | Solution structure of ring domain of E3 ubiquitin ligase DOA10 | solution nmr | A | — | — |
| 8PD0 | cryo-EM structure of Doa10 in MSP1E3D1 | electron microscopy | A | PCW, PX6 | 9 (best 0.83) |
| 8PDA | cryo-EM structure of Doa10 with RING domain in MSP1E3D1 | electron microscopy | A | PCW, PX6 | 10 (best 0.83) |
| 8TQM | Cryo-EM structure of E3 ubiquitin ligase Doa10 from Saccharomyces cerevisiae | electron microscopy | A | PC1, TGL, Y01, ERG | 11 (best 0.86) |
| P40318 | AlphaFold monomer V2.0 prediction for erad-associated E3 ubiquitin- protein ligase DOA10 (P40318) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8TQM chain A against the predicted model P40318: TM-score 0.93, RMSD 2.76 Å
- 8PD0 chain A against the predicted model P40318: TM-score 0.91, RMSD 3.47 Å
- 8PDA chain A against the predicted model P40318: TM-score 0.89, RMSD 3.89 Å
- 2M6M chain A against the predicted model P40318: TM-score 0.71, RMSD 1.81 Å
- 2M6M chain A against the predicted model P40318: TM-score 0.71, RMSD 1.81 Å
Elsewhere
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