UniProt P39524
Probable phospholipid-transporting ATPase DRS2,Probable phospholipid-transporting ATPase DRS2 (P39524)
Probable phospholipid-transporting ATPase DRS2,Probable phospholipid-transporting ATPase DRS2 (UniProt P39524), EC 7.2.4.2, 7.6.2.1: 16 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 50 pockets.…
- UniProt
- P39524
- Protein
- Probable phospholipid-transporting ATPase DRS2,Probable…
- EC
- 7.2.4.2, 7.6.2.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 50 · 3 records with a druggable one
Structures
17 records of P39524 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6PSX | Cryo-EM structure of S. cerevisiae DRS2P-CDC50P in the PI4P-activated form | electron microscopy | A | — | — |
| 6PSY | Cryo-EM structure of S. cerevisiae Drs2p-Cdc50p in the autoinhibited apo form | electron microscopy | A | — | — |
| 6PSY | Cryo-EM structure of S. cerevisiae DRS2P-CDC50P in the autoinhibited apo form | electron microscopy | A | — | — |
| 6ROH | Cryo-EM structure of the autoinhibited DRS2P-CDC50P | electron microscopy | A | MG | — |
| 6ROI | Cryo-EM structure of the partially activated Drs2p-Cdc50p | electron microscopy | A | MG, 2Y5 | — |
| 6ROI | Cryo-EM structure of the partially activated DRS2P-CDC50P | electron microscopy | A | MG, 2Y5 | — |
| 6ROJ | Cryo-EM structure of the activated Drs2p-Cdc50p | electron microscopy | A | MG, 2Y5 | 17 (best 0.79) |
| 6ROJ | Cryo-EM structure of the activated DRS2P-CDC50P | electron microscopy | A | MG, 2Y5 | — |
| 7OH4 | Cryo-EM structure of Drs2p-Cdc50p in the E1 state with PI4P and Mg2+ bound | electron microscopy | A | 2Y5, MG | 14 (best 0.78) |
| 7OH4 | Cryo-EM structure of DRS2P-CDC50P in the E1 state with PI4P and MG2+ bound | electron microscopy | A | 2Y5, MG | — |
| 7OH5 | Cryo-EM structure of Drs2p-Cdc50p in the E1-AlFx-ADP state | electron microscopy | A | MG, ALF, ADP, 2Y5 | 19 (best 0.81) |
| 7OH5 | Cryo-EM structure of DRS2P-CDC50P in the E1-alfx-ADP state | electron microscopy | A | ALF, MG, ADP, 2Y5 | — |
| 7OH6 | Cryo-EM structure of DRS2P-CDC50P in the [PS]E2-alfx state | electron microscopy | A | 2Y5, ALF, MG, Q3G | — |
| 7OH7 | Cryo-EM structure of DRS2P-CDC50P in the E1-amppcp state with PI4P bound | electron microscopy | A | 2Y5, ACP, MG | — |
| 7PEM | Cryo-EM structure of phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state | electron microscopy | A | 2Y5, MG, ATP, Q3G | — |
| 7PEM | Cryo-EM structure of phophorylated DRS2P-CDC50P in a ps and ATP-bound E2P state | electron microscopy | A | 2Y5, MG, ATP, Q3G | — |
| P39524 | AlphaFold monomer V2.0 prediction for probable phospholipid- transporting ATPase DRS2 (P39524) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 13 records
- 2Y5 · (2R)-1-{[(R)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy) propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate · in 12 records
- ALF · Tetrafluoroaluminate ion · in 3 records
- Q3G · O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy) propoxy](hydroxy)phosphoryl]-D-serine · in 3 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
Experiment against prediction
- 6ROH chain A against the predicted model P39524: TM-score 0.99, RMSD 0.94 Å
- 6ROI chain A against the predicted model P39524: TM-score 0.99, RMSD 1.11 Å
- 6ROI chain A against the predicted model P39524: TM-score 0.99, RMSD 1.11 Å
- 6PSY chain A against the predicted model P39524: TM-score 0.99, RMSD 1.34 Å
- 6PSY chain A against the predicted model P39524: TM-score 0.99, RMSD 1.34 Å
- 6ROJ chain A against the predicted model P39524: TM-score 0.98, RMSD 1.54 Å
- 6ROJ chain A against the predicted model P39524: TM-score 0.98, RMSD 1.54 Å
- 7PEM chain A against the predicted model P39524: TM-score 0.97, RMSD 1.85 Å
- 7PEM chain A against the predicted model P39524: TM-score 0.97, RMSD 1.85 Å
- 7OH4 chain A against the predicted model P39524: TM-score 0.90, RMSD 3.72 Å
Elsewhere
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