UniProt P39007
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (P39007)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 (UniProt P39007), EC 2.4.99.18: 8 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 49 pockets. Binding sites, druggability…
- UniProt
- P39007
- Protein
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- EC
- 2.4.99.18
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 49 · 4 records with a druggable one
Structures
9 records of P39007 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LGZ | Solution structure of STT3P | solution nmr | A | — | — |
| 2LGZ | Solution structure of STT3P | solution nmr | A | — | — |
| 6C26 | The cryo-EM structure of a eukaryotic oligosaccharyl transferase complex | electron microscopy | A | NAG, EGY | — |
| 6EZN | Cryo-EM structure of the yeast oligosaccharyltransferase (OST) complex | electron microscopy | F | NAG, CPL, PTY | 14 (best 0.77) |
| 6EZN | Cryo-EM structure of the yeast oligosaccharyltransferase (ost) complex | electron microscopy | F | NAG, CPL, PTY | — |
| 7OCI | Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex | electron microscopy | F | NAG, PEE, AJP, MG, V8K | 12 (best 0.74) |
| 7OCI | Cryo-EM structure of yeast OST6P containing oligosaccharyltransferase complex | electron microscopy | F | NAG, PEE, AJP, MG, V8K | — |
| 8AGB | Structure of yeast oligosaccharylransferase complex with lipid-linked oligosaccharide bound | electron microscopy | A | NAG, NDG, BMA, MAN, GLC, CPL | 14 (best 0.77) |
| P39007 | AlphaFold monomer V2.0 prediction for dolichyl- diphosphooligosaccharide--protein… | predicted | A | — | 9 (best 0.81) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- CPL · 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine · in 3 records
- PTY · Phosphatidylethanolamine · in 3 records
- AJP · Digitonin · in 2 records
- MG · Magnesium ion · in 2 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 2 records
- V8K · Dolichylphosphate · in 2 records
- BMA · beta-D-mannopyranose · in 1 record
- EGY · (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium · in 1 record
- ELU · phosphono [(3~{R},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- MN · Manganese (II) ion · in 1 record
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · in 1 record
Experiment against prediction
- 7OCI chain F against the predicted model P39007: TM-score 0.95, RMSD 1.55 Å
- 7OCI chain F against the predicted model P39007: TM-score 0.95, RMSD 1.55 Å
- 8AGB chain A against the predicted model P39007: TM-score 0.95, RMSD 1.62 Å
- 6EZN chain F against the predicted model P39007: TM-score 0.95, RMSD 1.69 Å
- 6EZN chain F against the predicted model P39007: TM-score 0.95, RMSD 1.69 Å
- 6C26 chain A against the predicted model P39007: TM-score 0.93, RMSD 2.03 Å
- 2LGZ chain A against the predicted model P39007: TM-score 0.37, RMSD 6.02 Å
- 2LGZ chain A against the predicted model P39007: TM-score 0.37, RMSD 6.02 Å
Elsewhere
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