UniProt P37821
1-aminocyclopropane-1-carboxylate synthase (P37821)
1-aminocyclopropane-1-carboxylate synthase (UniProt P37821), EC 4.4.1.14: 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P37821
- Protein
- 1-aminocyclopropane-1-carboxylate synthase
- EC
- 4.4.1.14
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 50 · 9 records with a druggable one
Structures
11 records of P37821 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B8G | 1-aminocyclopropane-1-carboxylate synthase | x-ray diffraction | A, B | PLP | 12 (best 0.75) |
| 1B8G | 1-aminocyclopropane-1-carboxylate synthase | x-ray diffraction | A, B | PLP | 12 (best 0.75) |
| 1M4N | Crystal structure of apple acc synthase in complex with… | x-ray diffraction | A | PLP, AAD | 3 (best 0.63) |
| 1M4N | Crystal structure of apple acc synthase in complex with [2-(amino… | x-ray diffraction | A | PLP, AAD | 3 (best 0.63) |
| 1M7Y | Crystal structure of apple ACC synthase in complex with L-aminoethoxyvinylglycine | x-ray diffraction | A | PPG | 3 (best 0.63) |
| 1M7Y | Crystal structure of apple acc synthase in complex with L- aminoethoxyvinylglycine | x-ray diffraction | A | PPG | 3 (best 0.63) |
| 1YNU | Crystal structure of apple ACC synthase in complex with L-vinylglycine | x-ray diffraction | A | NI, K, PY4 | 5 (best 0.62) |
| 1YNU | Crystal structure of apple acc synthase in complex with L-vinylglycine | x-ray diffraction | A | NI, K, PY4 | 5 (best 0.62) |
| 3PIU | High-resolution structure of native Malus domestica ACC synthase | x-ray diffraction | A | PLR | 4 (best 0.63) |
| 3PIU | High-resolution structure of native malus domestica acc synthase | x-ray diffraction | A | — | — |
| P37821 | AlphaFold monomer V2.0 prediction for 1-aminocyclopropane-1-carboxylate synthase (P37821) | predicted | A | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 4 records
- AAD · (2-aminooxy-ethyl)-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-methyl-sulfonium · in 2 records
- K · Potassium ion · in 2 records
- NI · Nickel (II) ion · in 2 records
- PPG · (2E,3E)-4-(2-aminoethoxy)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid · in 2 records
- PY4 · 2-[O-phosphonopyridoxyl]-amino- butyric acid · in 2 records
- PLR · (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate · in 1 record
Experiment against prediction
- 3PIU chain A against the predicted model P37821: TM-score 1.00, RMSD 0.43 Å
- 3PIU chain A against the predicted model P37821: TM-score 1.00, RMSD 0.43 Å
- 1B8G chain A against the predicted model P37821: TM-score 1.00, RMSD 0.43 Å
- 1B8G chain A against the predicted model P37821: TM-score 1.00, RMSD 0.43 Å
- 1M4N chain A against the predicted model P37821: TM-score 1.00, RMSD 0.52 Å
- 1M4N chain A against the predicted model P37821: TM-score 1.00, RMSD 0.52 Å
- 1M7Y chain A against the predicted model P37821: TM-score 0.99, RMSD 0.54 Å
- 1M7Y chain A against the predicted model P37821: TM-score 0.99, RMSD 0.54 Å
- 1B8G chain B against the predicted model P37821: TM-score 0.99, RMSD 0.60 Å
- 1B8G chain B against the predicted model P37821: TM-score 0.99, RMSD 0.60 Å
Elsewhere
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