UniProt P32660
Phospholipid-transporting ATPase DNF1 (P32660)
Phospholipid-transporting ATPase DNF1 (UniProt P32660), EC 7.6.2.1: 14 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 90 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P32660
- Protein
- Phospholipid-transporting ATPase DNF1
- EC
- 7.6.2.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 90 · 5 records with a druggable one
Structures
15 records of P32660 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7DRX | Cryo-EM structure of DNF1 from saccharomyces cerevisiae in 90PS with beryllium fluoride (E2P state) | electron microscopy | A | NAG, MG, BEF, 6PL | — |
| 7DSH | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with AMPPCP (E1-ATP state) | electron microscopy | A | NAG, ACP, MG | 20 (best 0.84) |
| 7DSH | Cryo-EM structure of DNF1 from saccharomyces cerevisiae in 90PS with amppcp (E1-ATP state) | electron microscopy | A | NAG, ACP, MG | — |
| 7DSI | Cryo-EM structure of DNF1 from saccharomyces cerevisiae in yeast lipids with amppcp ( resting state… | electron microscopy | A | ACP, MG | — |
| 7F7F | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with beryllium fluoride… | electron microscopy | A | NAG, MG | 20 (best 0.80) |
| 7F7F | Cryo-EM structure of DNF1 from saccharomyces cerevisiae in yeast lipids with beryllium fluoride… | electron microscopy | A | NAG, MG | — |
| 7KY6 | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf1-Lem3 complex in the apo E1 state | electron microscopy | A | NAG, MG | 18 (best 0.74) |
| 7KY6 | Structure of the S. cerevisiae phosphatidylcholine flippase DNF1-LEM3 complex in the apo E1 state | electron microscopy | A | NAG, MG | — |
| 7KYB | Structure of the S. cerevisiae phosphatidylcholine flippase DNF1-LEM3 complex in the E1-ADP state | electron microscopy | A | NAG, POV, ADP, ALF, MG | — |
| 7KYC | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf1-Lem3 complex in the E2P state | electron microscopy | A | NAG, BEF, MG, POV | 14 (best 0.77) |
| 7KYC | Structure of the S. cerevisiae phosphatidylcholine flippase DNF1-LEM3 complex in the E2P state | electron microscopy | A | NAG, BEF, MG, POV | — |
| 7WHV | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with beryllium fluoride (E2P… | electron microscopy | A | NAG, MG, BEF, 6PL | 18 (best 0.79) |
| 7WHV | Cryo-EM structure of DNF1 from saccharomyces cerevisiae in detergent with beryllium fluoride (E2P… | electron microscopy | A | NAG, MG, BEF, 6PL | — |
| 7WHW | Cryo-EM structure of DNF1 from saccharomyces cerevisiae in detergent with amppcp (E1-ATP state) | electron microscopy | A | NAG, ACP, MG | — |
| P32660 | AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase DNF1 (P32660) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 14 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 13 records
- BEF · Beryllium trifluoride ion · in 5 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 4 records
- 6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · in 3 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- ALF · Tetrafluoroaluminate ion · in 1 record
Experiment against prediction
- 7KYC chain A against the predicted model P32660: TM-score 0.99, RMSD 1.03 Å
- 7KYC chain A against the predicted model P32660: TM-score 0.99, RMSD 1.03 Å
- 7WHV chain A against the predicted model P32660: TM-score 0.98, RMSD 1.51 Å
- 7WHV chain A against the predicted model P32660: TM-score 0.98, RMSD 1.51 Å
- 7DRX chain A against the predicted model P32660: TM-score 0.97, RMSD 1.63 Å
- 7KY6 chain A against the predicted model P32660: TM-score 0.85, RMSD 4.77 Å
- 7KY6 chain A against the predicted model P32660: TM-score 0.85, RMSD 4.77 Å
- 7KYB chain A against the predicted model P32660: TM-score 0.80, RMSD 4.86 Å
- 7WHW chain A against the predicted model P32660: TM-score 0.78, RMSD 5.98 Å
- 7DSH chain A against the predicted model P32660: TM-score 0.77, RMSD 5.99 Å
Elsewhere
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