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MolNFT v1 · #180402 · protein

Structure of the S. cerevisiae phosphatidylcholine flippase DNF1-LEM3 complex in the E1-ADP state

7KYB: “Structure of the S. cerevisiae phosphatidylcholine flippase DNF1-LEM3 complex in the E1-ADP state”. Electron microscopy, 6 ligands (POV, ADP, ALF). MolNFT v1 #180402 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7KYB
Type
protein
Length
1,322 residues
Chains
2
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P32660, P42838
Ligands
POV, ADP, ALF, NAG, MAN, MG

Structure

electron microscopy · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein957—P32660
B—protein365—P42838

Ligands and binding sites

  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · chains A, B
  • ADP · Adenosine-5'-diphosphate · ligand · chains A
  • ALF · Tetrafluoroaluminate ion · ligand · chains A
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
  • MAN · alpha-D-mannopyranose · sugar
  • MG · Magnesium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7KYB · Structure of the S. cerevisiae phosphatidylcholine flippase Dnf1-Lem3 complex in the… · the same entry in another collection · chain A against A, TM-score 1.00
  • P42838 · AlphaFold monomer V2.0 prediction for alkylphosphocholine resistance protein LEM3 (P42838) · a predicted model of the same protein · chain B against A, TM-score 0.98
  • P32660 · AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase DNF1 (P32660) · a predicted model of the same protein · chain A against A, TM-score 0.80

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