UniProt P32563
V-type proton ATPase subunit a, vacuolar isoform (P32563)
V-type proton ATPase subunit a, vacuolar isoform (UniProt P32563): 28 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P32563
- Protein
- V-type proton ATPase subunit a, vacuolar isoform
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 2 records with a druggable one
Structures
29 records of P32563 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NVJ | NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase | solution nmr | A | — | — |
| 2NVJ | NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase | solution nmr | A | — | — |
| 2RPW | Structure of a peptide derived from H+-V-ATPase subunit a | solution nmr | X | — | — |
| 2RPW | Structure of a peptide derived from H+-V-ATPase subunit a | solution nmr | X | — | — |
| 3J9T | Yeast V-ATPase state 1 | electron microscopy | b | — | — |
| 3J9U | Yeast V-ATPase state 2 | electron microscopy | b | — | — |
| 3J9V | Yeast V-ATPase state 3 | electron microscopy | b | — | — |
| 5I1M | Yeast V-ATPase average of densities, a subunit segment | electron microscopy | V | — | 4 (best 0.50) |
| 5I1M | Yeast V-ATPase average of densities, a subunit segment | electron microscopy | V | — | — |
| 5TJ5 | Atomic model for the membrane-embedded motor of a eukaryotic V-ATPase | electron microscopy | A | — | — |
| 5VOX | Yeast V-ATPase in complex with legionella pneumophila effector sidk (rotational state 1) | electron microscopy | b | — | — |
| 5VOY | Yeast V-ATPase in complex with legionella pneumophila effector sidk (rotational state 2) | electron microscopy | b | — | — |
| 5VOZ | Yeast V-ATPase in complex with legionella pneumophila effector sidk (rotational state 3) | electron microscopy | b | — | — |
| 6C6L | Yeast vacuolar ATPase vo in lipid nanodisc | electron microscopy | A | — | — |
| 6HH0 | Yeast V-ATPase transmembrane helix 7 NMR structure in DPC micelles | solution nmr | A | — | — |
| 6HH0 | Yeast V-ATPase transmembrane helix 7 NMR structure in dpc micelles | solution nmr | A | — | — |
| 6M0R | 2.7A yeast vo STATE3 | electron microscopy | A | NAG, PEE, PPV, EYR | — |
| 6M0S | 3.6A yeast vo STATE3 prime | electron microscopy | A | — | — |
| 6O7T | Saccharomyces cerevisiae V-ATPase Vph1-VO | electron microscopy | a | — | — |
| 6O7T | Saccharomyces cerevisiae V-ATPase VPH1-vo | electron microscopy | a | — | — |
| 6PE4 | Yeast vo motor in complex with 1 vopq molecule | electron microscopy | A | — | — |
| 6PE5 | Yeast vo motor in complex with 2 vopq molecules | electron microscopy | A | — | — |
| 7FDA | Cryoem structure of reconstituted V-ATPase, STATE1 | electron microscopy | Q | — | — |
| 7FDB | Cryoem structures of reconstituted V-ATPASE,STATE2 | electron microscopy | Q | — | — |
| 7FDC | Cryoem structures of reconstituted V-ATPase, STATE3 | electron microscopy | Q | — | — |
| 7TAO | Cryo-EM structure of bafilomycin A1 bound to yeast vo V-ATPase | electron microscopy | A | WEV | — |
| 7TAP | Cryo-EM structure of archazolid a bound to yeast vo V-ATPase | electron microscopy | A | — | — |
| 7TMR | V-ATPase from saccharomyces cerevisiae, state 1 | electron microscopy | a | — | — |
| P32563 | AlphaFold monomer V2.0 prediction for V-type proton ATPase subunit a, vacuolar isoform (P32563) | predicted | A | — | 11 (best 0.69) |
Ligands
- EYR · (6~{E},10~{E},14~{E},18~{E},22~{E},26~{E},30~{R})-2,6, 10,14,18,22,26,30-octamethyldotriaconta-2,6,10,14,18, 22,26-heptaene · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
- PPV · Pyrophosphate · in 1 record
- WEV · (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S, 4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7, 9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12, 14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose · in 1 record
Experiment against prediction
- 6O7T chain a against the predicted model P32563: TM-score 0.91, RMSD 3.21 Å
- 6O7T chain a against the predicted model P32563: TM-score 0.91, RMSD 3.21 Å
- 7FDA chain Q against the predicted model P32563: TM-score 0.90, RMSD 3.22 Å
- 7TAO chain A against the predicted model P32563: TM-score 0.90, RMSD 3.32 Å
- 6M0R chain A against the predicted model P32563: TM-score 0.90, RMSD 3.59 Å
- 6PE4 chain A against the predicted model P32563: TM-score 0.90, RMSD 3.63 Å
- 7TAP chain A against the predicted model P32563: TM-score 0.90, RMSD 3.42 Å
- 6C6L chain A against the predicted model P32563: TM-score 0.90, RMSD 3.43 Å
- 6PE5 chain A against the predicted model P32563: TM-score 0.89, RMSD 3.57 Å
- 7TMR chain a against the predicted model P32563: TM-score 0.89, RMSD 3.50 Å
Elsewhere
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