UniProt P32245
Melanocortin receptor 4 (P32245)
Melanocortin receptor 4 (UniProt P32245): 19 experimental structures on GenesisL1, 4 ligands bound, 47 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P32245
- Protein
- Melanocortin receptor 4
- Experimental structures
- 19
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 47 · 10 records with a druggable one
Structures
19 records of P32245 in the MolNFT archive: 19 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6W25 | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119 | x-ray diffraction | A | CA, OLA | 5 (best 0.60) |
| 6W25 | Crystal structure of the melanocortin-4 receptor (MC4R) in complex with SHU9119 | x-ray diffraction | A | NH2, CA, OLA | — |
| 7AUE | Melanocortin receptor 4 (MC4R) Gs protein complex | electron microscopy | R | CA | 6 (best 0.74) |
| 7AUE | Melanocortin receptor 4 (MC4R) gs protein complex | electron microscopy | R | CA | — |
| 7F53 | Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex | electron microscopy | R | CA | 3 (best 0.77) |
| 7F53 | Cryo-EM structure of a-msh-MC4R-GS_NB35 complex | electron microscopy | R | CA | — |
| 7F54 | Cryo-EM structure of afamelanotide-MC4R-GS_NB35 complex | electron microscopy | R | CA | — |
| 7F55 | Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex | electron microscopy | R | CA | 4 (best 0.76) |
| 7F55 | Cryo-EM structure of bremelanotide-MC4R-GS_NB35 complex | electron microscopy | R | CA | — |
| 7F58 | Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex | electron microscopy | R | 1I8, CA | 5 (best 0.77) |
| 7F58 | Cryo-EM structure of thiq-MC4R-GS_NB35 complex | electron microscopy | R | 1I8, CA | — |
| 7PIU | Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R)… | electron microscopy | R | CA | 2 (best 0.77) |
| 7PIU | Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R)… | electron microscopy | R | CA | — |
| 7PIV | Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A… | electron microscopy | R | CA | 4 (best 0.77) |
| 7PIV | Active melanocortin-4 receptor (MC4R)- gs protein complex bound to agonist ndp-alpha-msh at 2.86 a… | electron microscopy | R | CA | — |
| 8QJ2 | Structure of active state MC4R in complex with a potent ligand mimicking nanobody | electron microscopy | A | — | 5 (best 0.72) |
| 8WKY | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25 | x-ray diffraction | A | CA, OLA | 6 (best 0.64) |
| 8WKZ | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31 | x-ray diffraction | A | CA, OLA | 7 (best 0.63) |
| P32245 | AlphaFold monomer V2.0 prediction for melanocortin receptor 4 (P32245) | — | — | — |
Ligands
Experiment against prediction
- 8QJ2 chain A against the predicted model P0ABE7: TM-score 0.29, RMSD 4.40 Å
- 8QJ2 chain A against the predicted model Q9U6Y8: TM-score 0.29, RMSD 5.62 Å
Elsewhere
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