UniProt P31941
DNA dC->dU-editing enzyme APOBEC-3A (P31941)
DNA dC->dU-editing enzyme APOBEC-3A (UniProt P31941), EC 3.5.4.-, 3.5.4.38: 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P31941
- Protein
- DNA dC->dU-editing enzyme APOBEC-3A
- EC
- 3.5.4.-, 3.5.4.38
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 23 · 3 records with a druggable one
Structures
15 records of P31941 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2M65 | NMR structure of human restriction factor APOBEC3A | solution nmr | A | — | — |
| 2M65 | NMR structure of human restriction factor APOBEC3A | solution nmr | A | — | — |
| 4XXO | Crystal Structure of Human APOBEC3A | x-ray diffraction | A, B | — | — |
| 4XXO | Crystal structure of human APOBEC3A | x-ray diffraction | A, B | — | — |
| 5KEG | Crystal structure of APOBEC3A in complex with a single-stranded DNA | x-ray diffraction | A | ZN, CA, CL | — |
| 5KEG | Crystal structure of APOBEC3A in complex with a single-stranded DNA | x-ray diffraction | A | ZN, CA, CL | — |
| 5SWW | Crystal structure of human APOBEC3A complexed with ssdna | x-ray diffraction | A, B, C, D | ZN | — |
| 7D3V | Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed… | solution nmr | A, B | ZN | 10 (best 0.73) |
| 7D3V | Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed… | solution nmr | A, B | ZN | — |
| 7D3W | Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed… | solution nmr | A | ZN | — |
| 7D3X | Non-specific and specific interactions work cooperatively to promote cytidine deamination catalyzed… | solution nmr | A | ZN | — |
| 8FIJ | Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 2) | x-ray diffraction | A, B | ZN, PO4 | 4 (best 0.45) |
| 8FIL | Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate | x-ray diffraction | A, B | IHP, CL | 4 (best 0.68) |
| 8FIM | Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate | x-ray diffraction | A, B | IHP, ZN, CL, PO4 | 5 (best 0.62) |
| P31941 | AlphaFold monomer V2.0 prediction for DNA dc->du-editing enzyme apobec-3A (P31941) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8FIJ chain A against the predicted model P31941: TM-score 0.99, RMSD 0.65 Å
- 8FIJ chain B against the predicted model P31941: TM-score 0.99, RMSD 0.68 Å
- 8FIM chain A against the predicted model P31941: TM-score 0.98, RMSD 0.67 Å
- 5KEG chain A against the predicted model P31941: TM-score 0.98, RMSD 0.68 Å
- 5KEG chain A against the predicted model P31941: TM-score 0.98, RMSD 0.68 Å
- 4XXO chain A against the predicted model P31941: TM-score 0.98, RMSD 0.93 Å
- 4XXO chain A against the predicted model P31941: TM-score 0.98, RMSD 0.93 Å
- 4XXO chain B against the predicted model P31941: TM-score 0.98, RMSD 0.93 Å
- 4XXO chain B against the predicted model P31941: TM-score 0.98, RMSD 0.93 Å
- 5SWW chain B against the predicted model P31941: TM-score 0.98, RMSD 0.97 Å
Elsewhere
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