UniProt P31939
Bifunctional purine biosynthesis protein atic (P31939)
Bifunctional purine biosynthesis protein atic (UniProt P31939): 9 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P31939
- Protein
- Bifunctional purine biosynthesis protein atic
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 6 · 1 record with a druggable one
Structures
10 records of P31939 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1P4R | Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD | x-ray diffraction | A, B | — | — |
| 1P4R | Crystal structure of human atic in complex with folate- based inhibitor BW1540U88UD | x-ray diffraction | A, B | — | — |
| 1PKX | Crystal Structure of human ATIC in complex with XMP | x-ray diffraction | A, B, C, D | — | — |
| 1PKX | Crystal structure of human atic in complex with xmp | x-ray diffraction | A, B, C, D | — | — |
| 1PL0 | Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC | x-ray diffraction | A, B, C, D | — | — |
| 1PL0 | Crystal structure of human atic in complex with folate- based inhibitor, BW2315U89UC | x-ray diffraction | A, B, C, D | — | — |
| 5UY8 | Crystal structure of aicarft bound to an antifolate | x-ray diffraction | A, B, C, D | 8UM, AMZ, MG | — |
| 5UZ0 | Crystal structure of AICARFT bound to an antifolate | x-ray diffraction | A, B, C, D | AMZ, MG, 8US | — |
| 5UZ0 | Crystal structure of aicarft bound to an antifolate | x-ray diffraction | A, B, C, D | AMZ, MG, 8US | — |
| P31939 | AlphaFold monomer V2.0 prediction for bifunctional purine biosynthesis protein atic (P31939) | predicted | A | — | 6 (best 0.69) |
Ligands
- AMZ · Aminoimidazole 4-carboxamide ribonucleotide · in 3 records
- MG · Magnesium ion · in 3 records
- 8US · N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide · in 2 records
- 8UM · 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide · in 1 record
Experiment against prediction
- 1PKX chain C against the predicted model P31939: TM-score 1.00, RMSD 0.46 Å
- 1PKX chain C against the predicted model P31939: TM-score 1.00, RMSD 0.46 Å
- 1PKX chain A against the predicted model P31939: TM-score 1.00, RMSD 0.48 Å
- 1PKX chain A against the predicted model P31939: TM-score 1.00, RMSD 0.48 Å
- 1PL0 chain C against the predicted model P31939: TM-score 0.99, RMSD 0.63 Å
- 1PL0 chain C against the predicted model P31939: TM-score 0.99, RMSD 0.63 Å
- 1PL0 chain A against the predicted model P31939: TM-score 0.99, RMSD 0.64 Å
- 1PL0 chain A against the predicted model P31939: TM-score 0.99, RMSD 0.64 Å
- 5UY8 chain A against the predicted model P31939: TM-score 0.99, RMSD 0.66 Å
- 5UZ0 chain A against the predicted model P31939: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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